Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)    
Predicted Functional Partners:
CDK5
Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.
    
 0.965
ENSANAP00000024200
Protein kinase domain-containing protein.
    
 0.947
CRMP1
Collapsin response mediator protein 1.
   
 
  0.618
NRP1
Neuropilin; Belongs to the neuropilin family.
     
  0.551
DPYSL4
Dihydropyrimidinase like 4.
   
 
  0.538
TP73
Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
    
 0.532
TP63
Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
    
 0.508
AMPH
Amphiphysin.
    
   0.506
CTNNB1
Catenin beta 1.
    
   0.506
CDK5R1
Cyclin-dependent kinase 5 activator.
  
 
 
0.496
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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