TICAM2 protein (Aotus nancymaae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TICAM2

Toll like receptor adaptor molecule 2. (238 aa)

Predicted Functional Partners:

TLR4

0.992

TRAF6

0.991

RIPK1

0.986

TICAM1

0.979

LOC105722888

0.944

TMED2

0.917

TBK1

0.895

TRAF3

0.893

TLR3

0.891

MAP3K7

0.878

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC105722888	TBK1	ENSANAP00000022254	ENSANAP00000021446	TIR domain-containing protein.	TANK binding kinase 1.	0.556
LOC105722888	TICAM1	ENSANAP00000022254	ENSANAP00000009967	TIR domain-containing protein.	Toll like receptor adaptor molecule 1.	0.955
LOC105722888	TICAM2	ENSANAP00000022254	ENSANAP00000001685	TIR domain-containing protein.	Toll like receptor adaptor molecule 2.	0.944
LOC105722888	TLR3	ENSANAP00000022254	ENSANAP00000009875	TIR domain-containing protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.820
LOC105722888	TLR4	ENSANAP00000022254	ENSANAP00000017232	TIR domain-containing protein.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.940
LOC105722888	TRAF3	ENSANAP00000022254	ENSANAP00000009518	TIR domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.421
LOC105722888	TRAF6	ENSANAP00000022254	ENSANAP00000020369	TIR domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.633
MAP3K7	RIPK1	ENSANAP00000018427	ENSANAP00000031154	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	Receptor interacting serine/threonine kinase 1.	0.995
MAP3K7	TICAM1	ENSANAP00000018427	ENSANAP00000009967	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	Toll like receptor adaptor molecule 1.	0.879
MAP3K7	TICAM2	ENSANAP00000018427	ENSANAP00000001685	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	Toll like receptor adaptor molecule 2.	0.878
MAP3K7	TLR3	ENSANAP00000018427	ENSANAP00000009875	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.929
MAP3K7	TLR4	ENSANAP00000018427	ENSANAP00000017232	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.955
MAP3K7	TRAF3	ENSANAP00000018427	ENSANAP00000009518	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.960
MAP3K7	TRAF6	ENSANAP00000018427	ENSANAP00000020369	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
RIPK1	MAP3K7	ENSANAP00000031154	ENSANAP00000018427	Receptor interacting serine/threonine kinase 1.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.995
RIPK1	TBK1	ENSANAP00000031154	ENSANAP00000021446	Receptor interacting serine/threonine kinase 1.	TANK binding kinase 1.	0.755
RIPK1	TICAM1	ENSANAP00000031154	ENSANAP00000009967	Receptor interacting serine/threonine kinase 1.	Toll like receptor adaptor molecule 1.	0.994
RIPK1	TICAM2	ENSANAP00000031154	ENSANAP00000001685	Receptor interacting serine/threonine kinase 1.	Toll like receptor adaptor molecule 2.	0.986
RIPK1	TLR3	ENSANAP00000031154	ENSANAP00000009875	Receptor interacting serine/threonine kinase 1.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.960
RIPK1	TLR4	ENSANAP00000031154	ENSANAP00000017232	Receptor interacting serine/threonine kinase 1.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.744