DGCR8 protein (Aotus nancymaae) - STRING interaction network

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Score

DGCR8

DGCR8 microprocessor complex subunit. (773 aa)

Predicted Functional Partners:

DROSHA

0.996

DICER1

0.948

MRPL44

0.867

USP36

0.841

DDX5

0.832

DDX17

0.830

ERH

0.800

MDC1

0.784

AGO2

0.782

TARBP2

0.766

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	DGCR8	ENSANAP00000019263	ENSANAP00000001691	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DGCR8 microprocessor complex subunit.	0.782
AGO2	DICER1	ENSANAP00000019263	ENSANAP00000011480	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.996
AGO2	DROSHA	ENSANAP00000019263	ENSANAP00000005466	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Drosha ribonuclease III.	0.876
AGO2	MRPL44	ENSANAP00000019263	ENSANAP00000042176	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Mitochondrial ribosomal protein L44.	0.692
AGO2	TARBP2	ENSANAP00000019263	ENSANAP00000033648	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.989
DDX17	DDX5	ENSANAP00000035084	ENSANAP00000001239	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.996
DDX17	DGCR8	ENSANAP00000035084	ENSANAP00000001691	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DGCR8 microprocessor complex subunit.	0.830
DDX17	DROSHA	ENSANAP00000035084	ENSANAP00000005466	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Drosha ribonuclease III.	0.907
DDX5	DDX17	ENSANAP00000001239	ENSANAP00000035084	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.996
DDX5	DGCR8	ENSANAP00000001239	ENSANAP00000001691	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DGCR8 microprocessor complex subunit.	0.832
DDX5	DROSHA	ENSANAP00000001239	ENSANAP00000005466	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Drosha ribonuclease III.	0.990
DGCR8	AGO2	ENSANAP00000001691	ENSANAP00000019263	DGCR8 microprocessor complex subunit.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.782
DGCR8	DDX17	ENSANAP00000001691	ENSANAP00000035084	DGCR8 microprocessor complex subunit.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.830
DGCR8	DDX5	ENSANAP00000001691	ENSANAP00000001239	DGCR8 microprocessor complex subunit.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.832
DGCR8	DICER1	ENSANAP00000001691	ENSANAP00000011480	DGCR8 microprocessor complex subunit.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.948
DGCR8	DROSHA	ENSANAP00000001691	ENSANAP00000005466	DGCR8 microprocessor complex subunit.	Drosha ribonuclease III.	0.996
DGCR8	ERH	ENSANAP00000001691	ENSANAP00000013425	DGCR8 microprocessor complex subunit.	Enhancer of rudimentary homolog; May have a role in the cell cycle.	0.800
DGCR8	MDC1	ENSANAP00000001691	ENSANAP00000014526	DGCR8 microprocessor complex subunit.	Mediator of DNA damage checkpoint 1.	0.784
DGCR8	MRPL44	ENSANAP00000001691	ENSANAP00000042176	DGCR8 microprocessor complex subunit.	Mitochondrial ribosomal protein L44.	0.867
DGCR8	TARBP2	ENSANAP00000001691	ENSANAP00000033648	DGCR8 microprocessor complex subunit.	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.766