Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TIGITT cell immunoreceptor with Ig and ITIM domains. (297 aa)    
Predicted Functional Partners:
NECTIN2
Nectin cell adhesion molecule 2.
    
 0.996
PVR
PVR cell adhesion molecule.
    
 0.993
NECTIN3
Nectin cell adhesion molecule 3.
    
 0.970
CD4
Ig-like domain-containing protein.
      
 0.803
CD96
CD96 molecule.
   
  
 0.736
CD226
CD226 molecule.
   
 
 0.715
LAG3
Lymphocyte activating 3.
   
  
 0.677
CD244
CD244 molecule.
   
  
 0.653
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
   
  
 0.647
CD8A
CD8a molecule.
   
  
 0.645
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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