NGF protein (Aotus nancymaae) - STRING interaction network

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Score

NGF

Nerve growth factor; Belongs to the NGF-beta family. (241 aa)

Predicted Functional Partners:

NTRK1

0.995

NGFR

0.984

NTRK2

0.966

NTRK3

0.966

BDNF

0.913

SORCS2

0.913

KLK1

0.858

SORT1

0.838

MET

0.826

EGFR

0.826

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	EGFR	ENSANAP00000014207	ENSANAP00000037076	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Epidermal growth factor receptor.	0.811
BDNF	MET	ENSANAP00000014207	ENSANAP00000009807	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.865
BDNF	NGF	ENSANAP00000014207	ENSANAP00000001766	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Nerve growth factor; Belongs to the NGF-beta family.	0.913
BDNF	NGFR	ENSANAP00000014207	ENSANAP00000006952	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Nerve growth factor receptor.	0.896
BDNF	NTRK1	ENSANAP00000014207	ENSANAP00000027419	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.916
BDNF	NTRK2	ENSANAP00000014207	ENSANAP00000033227	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.981
BDNF	NTRK3	ENSANAP00000014207	ENSANAP00000035300	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.862
BDNF	SORCS2	ENSANAP00000014207	ENSANAP00000029815	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Sortilin related VPS10 domain containing receptor 2.	0.534
BDNF	SORT1	ENSANAP00000014207	ENSANAP00000006152	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Sortilin.	0.856
EGFR	BDNF	ENSANAP00000037076	ENSANAP00000014207	Epidermal growth factor receptor.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.811
EGFR	MET	ENSANAP00000037076	ENSANAP00000009807	Epidermal growth factor receptor.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.968
EGFR	NGF	ENSANAP00000037076	ENSANAP00000001766	Epidermal growth factor receptor.	Nerve growth factor; Belongs to the NGF-beta family.	0.826
EGFR	NTRK1	ENSANAP00000037076	ENSANAP00000027419	Epidermal growth factor receptor.	Tyrosine-protein kinase receptor.	0.450
EGFR	NTRK2	ENSANAP00000037076	ENSANAP00000033227	Epidermal growth factor receptor.	Tyrosine-protein kinase receptor.	0.634
EGFR	NTRK3	ENSANAP00000037076	ENSANAP00000035300	Epidermal growth factor receptor.	Tyrosine-protein kinase receptor.	0.557
KLK1	MET	ENSANAP00000018425	ENSANAP00000009807	Kallikrein 1; Belongs to the peptidase S1 family.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.665
KLK1	NGF	ENSANAP00000018425	ENSANAP00000001766	Kallikrein 1; Belongs to the peptidase S1 family.	Nerve growth factor; Belongs to the NGF-beta family.	0.858
KLK1	NTRK1	ENSANAP00000018425	ENSANAP00000027419	Kallikrein 1; Belongs to the peptidase S1 family.	Tyrosine-protein kinase receptor.	0.511
MET	BDNF	ENSANAP00000009807	ENSANAP00000014207	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.865
MET	EGFR	ENSANAP00000009807	ENSANAP00000037076	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Epidermal growth factor receptor.	0.968