Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
NGFNerve growth factor; Belongs to the NGF-beta family. (241 aa)    
Predicted Functional Partners:
NTRK1
Tyrosine-protein kinase receptor.
    
 0.999
NGFR
Nerve growth factor receptor.
    
 0.997
NTRK3
Tyrosine-protein kinase receptor.
    
 0.983
NTRK2
Tyrosine-protein kinase receptor.
    
 0.982
SORT1
Sortilin.
    
 
 0.927
BDNF
Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
   
 0.915
SORCS2
Sortilin related VPS10 domain containing receptor 2.
    
 
 0.898
KLK1
Kallikrein 1; Belongs to the peptidase S1 family.
    
 
 0.744
PDGFRA
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
  
  
 0.742
SORCS1
Sortilin related VPS10 domain containing receptor 1.
    
 
 0.735
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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