Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta 1.
    
 0.985
CACYBP
Uncharacterized protein.
    
 0.980
LOC105719658
Ubiquitin-like domain-containing protein.
     
  0.942
RPS27A
Ubiquitin-like domain-containing protein.
     
  0.942
UBA52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
     
  0.937
LOC105732229
Ubiquitin-like domain-containing protein.
     
 0.935
PINK1
PTEN induced kinase 1.
    
 0.925
SNCA
Alpha-synuclein; Belongs to the synuclein family.
    
 0.913
UBB
Uncharacterized protein.
     
 0.911
FKBP8
Peptidylprolyl isomerase.
   
 
 0.907
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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