STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNS3Tensin 3. (1580 aa)    
Predicted Functional Partners:
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
   
 0.961
MST1R
Macrophage stimulating 1 receptor.
   
 0.961
PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
    
 0.896
INPPL1
Inositol polyphosphate phosphatase like 1.
   
 
 0.864
SPRTN
SprT-like N-terminal domain.
   
    0.809
PIKFYVE
Phosphoinositide kinase, FYVE-type zinc finger containing.
     
 0.804
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase.
  
 0.801
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
    
 0.780
EGFR
Epidermal growth factor receptor.
    
 
 0.770
PI4KA
Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.
     
 0.766
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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