HTR4 protein (Aotus nancymaae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

HTR4

5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (427 aa)

Predicted Functional Partners:

LOC105727565

0.936

HTR6

0.935

HTR7

0.935

VIP

0.914

POMC

0.913

ADCYAP1

0.906

CGA

0.905

GCG

0.903

NPPA

0.900

LOC105727567

0.900

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCYAP1	GCG	ENSANAP00000027157	ENSANAP00000030394	Adenylate cyclase activating polypeptide 1.	Glucagon.	0.508
ADCYAP1	HTR4	ENSANAP00000027157	ENSANAP00000002175	Adenylate cyclase activating polypeptide 1.	5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.906
ADCYAP1	HTR6	ENSANAP00000027157	ENSANAP00000033523	Adenylate cyclase activating polypeptide 1.	5-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.919
ADCYAP1	LOC105727565	ENSANAP00000027157	ENSANAP00000002419	Adenylate cyclase activating polypeptide 1.	GNAS complex locus.	0.653
ADCYAP1	POMC	ENSANAP00000027157	ENSANAP00000018174	Adenylate cyclase activating polypeptide 1.	Proopiomelanocortin.	0.574
CGA	HTR4	ENSANAP00000015108	ENSANAP00000002175	Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.	5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.905
CGA	HTR6	ENSANAP00000015108	ENSANAP00000033523	Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.	5-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.900
CGA	LOC105727565	ENSANAP00000015108	ENSANAP00000002419	Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.	GNAS complex locus.	0.471
CGA	POMC	ENSANAP00000015108	ENSANAP00000018174	Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.	Proopiomelanocortin.	0.863
GCG	ADCYAP1	ENSANAP00000030394	ENSANAP00000027157	Glucagon.	Adenylate cyclase activating polypeptide 1.	0.508
GCG	HTR4	ENSANAP00000030394	ENSANAP00000002175	Glucagon.	5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.903
GCG	HTR6	ENSANAP00000030394	ENSANAP00000033523	Glucagon.	5-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.903
GCG	LOC105727565	ENSANAP00000030394	ENSANAP00000002419	Glucagon.	GNAS complex locus.	0.696
GCG	POMC	ENSANAP00000030394	ENSANAP00000018174	Glucagon.	Proopiomelanocortin.	0.616
HTR4	ADCYAP1	ENSANAP00000002175	ENSANAP00000027157	5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Adenylate cyclase activating polypeptide 1.	0.906
HTR4	CGA	ENSANAP00000002175	ENSANAP00000015108	5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.	0.905
HTR4	GCG	ENSANAP00000002175	ENSANAP00000030394	5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Glucagon.	0.903
HTR4	HTR6	ENSANAP00000002175	ENSANAP00000033523	5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family.	5-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.935
HTR4	HTR7	ENSANAP00000002175	ENSANAP00000040484	5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family.	5-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.935
HTR4	LOC105727565	ENSANAP00000002175	ENSANAP00000002419	5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family.	GNAS complex locus.	0.936