node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AADAT | AASDH | ENSANAP00000002550 | ENSANAP00000036902 | Aminoadipate aminotransferase. | Aminoadipate-semialdehyde dehydrogenase. | 0.900 |
AADAT | AFMID | ENSANAP00000002550 | ENSANAP00000042267 | Aminoadipate aminotransferase. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.936 |
AADAT | BCAT2 | ENSANAP00000002550 | ENSANAP00000004711 | Aminoadipate aminotransferase. | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.857 |
AADAT | DHTKD1 | ENSANAP00000002550 | ENSANAP00000008420 | Aminoadipate aminotransferase. | Dehydrogenase E1 and transketolase domain containing 1. | 0.895 |
AADAT | DLD | ENSANAP00000002550 | ENSANAP00000004604 | Aminoadipate aminotransferase. | Dihydrolipoyl dehydrogenase. | 0.904 |
AADAT | GOT1 | ENSANAP00000002550 | ENSANAP00000000033 | Aminoadipate aminotransferase. | Aspartate aminotransferase. | 0.877 |
AADAT | KMO | ENSANAP00000002550 | ENSANAP00000029020 | Aminoadipate aminotransferase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.955 |
AADAT | KYAT1 | ENSANAP00000002550 | ENSANAP00000033706 | Aminoadipate aminotransferase. | Aminotran_1_2 domain-containing protein. | 0.934 |
AADAT | KYAT3 | ENSANAP00000002550 | ENSANAP00000007337 | Aminoadipate aminotransferase. | Kynurenine aminotransferase 3. | 0.942 |
AADAT | KYNU | ENSANAP00000002550 | ENSANAP00000036892 | Aminoadipate aminotransferase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.935 |
AASDH | AADAT | ENSANAP00000036902 | ENSANAP00000002550 | Aminoadipate-semialdehyde dehydrogenase. | Aminoadipate aminotransferase. | 0.900 |
AASDH | AFMID | ENSANAP00000036902 | ENSANAP00000042267 | Aminoadipate-semialdehyde dehydrogenase. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.457 |
AASDH | BCAT2 | ENSANAP00000036902 | ENSANAP00000004711 | Aminoadipate-semialdehyde dehydrogenase. | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.843 |
AASDH | DLD | ENSANAP00000036902 | ENSANAP00000004604 | Aminoadipate-semialdehyde dehydrogenase. | Dihydrolipoyl dehydrogenase. | 0.416 |
AASDH | KMO | ENSANAP00000036902 | ENSANAP00000029020 | Aminoadipate-semialdehyde dehydrogenase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.889 |
AASDH | KYAT1 | ENSANAP00000036902 | ENSANAP00000033706 | Aminoadipate-semialdehyde dehydrogenase. | Aminotran_1_2 domain-containing protein. | 0.481 |
AASDH | KYAT3 | ENSANAP00000036902 | ENSANAP00000007337 | Aminoadipate-semialdehyde dehydrogenase. | Kynurenine aminotransferase 3. | 0.481 |
AASDH | KYNU | ENSANAP00000036902 | ENSANAP00000036892 | Aminoadipate-semialdehyde dehydrogenase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.434 |
AFMID | AADAT | ENSANAP00000042267 | ENSANAP00000002550 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Aminoadipate aminotransferase. | 0.936 |
AFMID | AASDH | ENSANAP00000042267 | ENSANAP00000036902 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Aminoadipate-semialdehyde dehydrogenase. | 0.457 |