BRAT1 protein (Aotus nancymaae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

BRAT1

BRCA1 associated ATM activator 1. (819 aa)

Predicted Functional Partners:

E4F1

0.769

BRCA1

0.628

NLRP7

0.571

RALB

0.571

TELO2

0.502

FAAP100

0.502

ATF3

0.476

BRAP

0.465

LRRC14

0.453

INCA1

0.432

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF3	BRAT1	ENSANAP00000039256	ENSANAP00000002809	Activating transcription factor 3.	BRCA1 associated ATM activator 1.	0.476
BRAP	BRAT1	ENSANAP00000038714	ENSANAP00000002809	BRCA1 associated protein.	BRCA1 associated ATM activator 1.	0.465
BRAP	BRCA1	ENSANAP00000038714	ENSANAP00000004329	BRCA1 associated protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.611
BRAP	RALB	ENSANAP00000038714	ENSANAP00000041652	BRCA1 associated protein.	RAS like proto-oncogene B.	0.501
BRAT1	ATF3	ENSANAP00000002809	ENSANAP00000039256	BRCA1 associated ATM activator 1.	Activating transcription factor 3.	0.476
BRAT1	BRAP	ENSANAP00000002809	ENSANAP00000038714	BRCA1 associated ATM activator 1.	BRCA1 associated protein.	0.465
BRAT1	BRCA1	ENSANAP00000002809	ENSANAP00000004329	BRCA1 associated ATM activator 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.628
BRAT1	E4F1	ENSANAP00000002809	ENSANAP00000041847	BRCA1 associated ATM activator 1.	E4F transcription factor 1.	0.769
BRAT1	FAAP100	ENSANAP00000002809	ENSANAP00000041625	BRCA1 associated ATM activator 1.	FA core complex associated protein 100.	0.502
BRAT1	INCA1	ENSANAP00000002809	ENSANAP00000041460	BRCA1 associated ATM activator 1.	Inhibitor of CDK, cyclin A1 interacting protein 1.	0.432
BRAT1	LRRC14	ENSANAP00000002809	ENSANAP00000029699	BRCA1 associated ATM activator 1.	Leucine rich repeat containing 14.	0.453
BRAT1	NLRP7	ENSANAP00000002809	ENSANAP00000031681	BRCA1 associated ATM activator 1.	NLR family pyrin domain containing 7.	0.571
BRAT1	RALB	ENSANAP00000002809	ENSANAP00000041652	BRCA1 associated ATM activator 1.	RAS like proto-oncogene B.	0.571
BRAT1	TELO2	ENSANAP00000002809	ENSANAP00000035950	BRCA1 associated ATM activator 1.	Telomere maintenance 2.	0.502
BRCA1	BRAP	ENSANAP00000004329	ENSANAP00000038714	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 associated protein.	0.611
BRCA1	BRAT1	ENSANAP00000004329	ENSANAP00000002809	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 associated ATM activator 1.	0.628
E4F1	BRAT1	ENSANAP00000041847	ENSANAP00000002809	E4F transcription factor 1.	BRCA1 associated ATM activator 1.	0.769
E4F1	FAAP100	ENSANAP00000041847	ENSANAP00000041625	E4F transcription factor 1.	FA core complex associated protein 100.	0.605
E4F1	LRRC14	ENSANAP00000041847	ENSANAP00000029699	E4F transcription factor 1.	Leucine rich repeat containing 14.	0.715
E4F1	TELO2	ENSANAP00000041847	ENSANAP00000035950	E4F transcription factor 1.	Telomere maintenance 2.	0.679