STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)    
Predicted Functional Partners:
CBL
Cbl proto-oncogene.
    
 0.726
CBLB
Cbl proto-oncogene B.
    
 0.647
CBLC
Cbl proto-oncogene C.
    
 0.623
GRB2
Growth factor receptor bound protein 2.
    
 
 0.610
SPRY2
Sprouty RTK signaling antagonist 2.
  
0.605
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
     
 0.585
ENSANAP00000012545
DUF3456 domain-containing protein.
      
 0.578
EGFR
Epidermal growth factor receptor.
     
 0.557
SPRY4
Sprouty RTK signaling antagonist 4.
   
0.552
SPRY3
Sprouty RTK signaling antagonist 3.
   
0.539
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.