STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GSDMDGasdermin D. (481 aa)    
Predicted Functional Partners:
CASP4
Caspase 4; Belongs to the peptidase C14A family.
   
 0.993
LOC105719329
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.993
ENSANAP00000021346
CARD domain-containing protein.
   
 0.948
NLRP3
NLR family pyrin domain containing 3.
     
 0.942
LOC105709175
Caspase recruitment domain family member 17.
   
 0.889
CARD18
Caspase recruitment domain family member 18.
   
 0.865
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
    
 0.788
IL1A
Interleukin-1; Belongs to the IL-1 family.
    
 0.726
NLRP1
NLR family pyrin domain containing 1.
     
 0.724
CARD8
Caspase recruitment domain family member 8.
    
 0.719
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.