STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)    
Predicted Functional Partners:
MAP3K4
Mitogen-activated protein kinase kinase kinase 4.
    
 0.966
CCNB1
Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.
    
 0.936
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
    
 0.926
GADD45A
Growth arrest and DNA damage inducible alpha.
  
0.922
ENSANAP00000034995
Uncharacterized protein; Belongs to the cyclin family.
    
 0.914
GADD45B
Growth arrest and DNA damage inducible beta.
  
 
0.893
ENSANAP00000001973
Cyclin N-terminal domain-containing protein.
    
 0.798
CCNB2
Cyclin B2; Belongs to the cyclin family.
    
 0.798
ENSANAP00000016389
Uncharacterized protein; Belongs to the cyclin family.
    
 0.742
TP73
Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
     
 0.573
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.