| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COMT | CYP1B1 | ENSANAP00000012538 | ENSANAP00000006842 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.942 |
| COMT | LOC105731574 | ENSANAP00000012538 | ENSANAP00000025042 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.939 |
| CYP1B1 | COMT | ENSANAP00000006842 | ENSANAP00000012538 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | 0.942 |
| CYP1B1 | EPHX1 | ENSANAP00000006842 | ENSANAP00000019428 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.939 |
| CYP1B1 | GSTP1 | ENSANAP00000006842 | ENSANAP00000027436 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Glutathione S-transferase pi 1; Belongs to the GST superfamily. | 0.938 |
| CYP1B1 | HPGDS | ENSANAP00000006842 | ENSANAP00000014948 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Hematopoietic prostaglandin D synthase. | 0.926 |
| CYP1B1 | HSD17B12 | ENSANAP00000006842 | ENSANAP00000000141 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.917 |
| CYP1B1 | HSD17B7 | ENSANAP00000006842 | ENSANAP00000011673 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Hydroxysteroid 17-beta dehydrogenase 7. | 0.922 |
| CYP1B1 | HSD17B8 | ENSANAP00000006842 | ENSANAP00000004927 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Hydroxysteroid 17-beta dehydrogenase 8. | 0.922 |
| CYP1B1 | IDO2 | ENSANAP00000006842 | ENSANAP00000037310 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Indoleamine 2,3-dioxygenase 2. | 0.920 |
| CYP1B1 | LOC105731574 | ENSANAP00000006842 | ENSANAP00000025042 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.928 |
| CYP1B1 | SULT2A1 | ENSANAP00000006842 | ENSANAP00000000972 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.916 |
| EPHX1 | CYP1B1 | ENSANAP00000019428 | ENSANAP00000006842 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.939 |
| EPHX1 | GSTP1 | ENSANAP00000019428 | ENSANAP00000027436 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | Glutathione S-transferase pi 1; Belongs to the GST superfamily. | 0.951 |
| EPHX1 | HPGDS | ENSANAP00000019428 | ENSANAP00000014948 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | Hematopoietic prostaglandin D synthase. | 0.935 |
| GSTP1 | CYP1B1 | ENSANAP00000027436 | ENSANAP00000006842 | Glutathione S-transferase pi 1; Belongs to the GST superfamily. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.938 |
| GSTP1 | EPHX1 | ENSANAP00000027436 | ENSANAP00000019428 | Glutathione S-transferase pi 1; Belongs to the GST superfamily. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.951 |
| GSTP1 | HPGDS | ENSANAP00000027436 | ENSANAP00000014948 | Glutathione S-transferase pi 1; Belongs to the GST superfamily. | Hematopoietic prostaglandin D synthase. | 0.788 |
| HPGDS | CYP1B1 | ENSANAP00000014948 | ENSANAP00000006842 | Hematopoietic prostaglandin D synthase. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.926 |
| HPGDS | EPHX1 | ENSANAP00000014948 | ENSANAP00000019428 | Hematopoietic prostaglandin D synthase. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.935 |