| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IL1B | PYCARD | ENSANAP00000000520 | ENSANAP00000001569 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | PYD and CARD domain containing. | 0.935 |
| IL1B | RIPK2 | ENSANAP00000000520 | ENSANAP00000025668 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | 0.402 |
| IL1B | RNH1 | ENSANAP00000000520 | ENSANAP00000007054 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Uncharacterized protein. | 0.409 |
| IL1B | TXNIP | ENSANAP00000000520 | ENSANAP00000023373 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Thioredoxin interacting protein. | 0.499 |
| LOC105726407 | RNH1 | ENSANAP00000001647 | ENSANAP00000007054 | RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. | Uncharacterized protein. | 0.797 |
| MAVS | RNH1 | ENSANAP00000009756 | ENSANAP00000007054 | Mitochondrial antiviral signaling protein. | Uncharacterized protein. | 0.423 |
| PYCARD | IL1B | ENSANAP00000001569 | ENSANAP00000000520 | PYD and CARD domain containing. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.935 |
| PYCARD | RNH1 | ENSANAP00000001569 | ENSANAP00000007054 | PYD and CARD domain containing. | Uncharacterized protein. | 0.559 |
| RIPK2 | IL1B | ENSANAP00000025668 | ENSANAP00000000520 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.402 |
| RIPK2 | RNH1 | ENSANAP00000025668 | ENSANAP00000007054 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | Uncharacterized protein. | 0.518 |
| RNH1 | IL1B | ENSANAP00000007054 | ENSANAP00000000520 | Uncharacterized protein. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.409 |
| RNH1 | LOC105726407 | ENSANAP00000007054 | ENSANAP00000001647 | Uncharacterized protein. | RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. | 0.797 |
| RNH1 | MAVS | ENSANAP00000007054 | ENSANAP00000009756 | Uncharacterized protein. | Mitochondrial antiviral signaling protein. | 0.423 |
| RNH1 | PYCARD | ENSANAP00000007054 | ENSANAP00000001569 | Uncharacterized protein. | PYD and CARD domain containing. | 0.559 |
| RNH1 | RIPK2 | ENSANAP00000007054 | ENSANAP00000025668 | Uncharacterized protein. | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | 0.518 |
| RNH1 | TXNIP | ENSANAP00000007054 | ENSANAP00000023373 | Uncharacterized protein. | Thioredoxin interacting protein. | 0.432 |
| RNH1 | USP14 | ENSANAP00000007054 | ENSANAP00000014624 | Uncharacterized protein. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.400 |
| TXNIP | IL1B | ENSANAP00000023373 | ENSANAP00000000520 | Thioredoxin interacting protein. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.499 |
| TXNIP | RNH1 | ENSANAP00000023373 | ENSANAP00000007054 | Thioredoxin interacting protein. | Uncharacterized protein. | 0.432 |
| USP14 | RNH1 | ENSANAP00000014624 | ENSANAP00000007054 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | Uncharacterized protein. | 0.400 |