| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMD1 | LOC105707196 | ENSANAP00000019431 | ENSANAP00000017605 | S-adenosylmethionine decarboxylase proenzyme. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.695 |
| AMD1 | LOC105734258 | ENSANAP00000019431 | ENSANAP00000036735 | S-adenosylmethionine decarboxylase proenzyme. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.868 |
| AMD1 | MAT1A | ENSANAP00000019431 | ENSANAP00000007520 | S-adenosylmethionine decarboxylase proenzyme. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.925 |
| AMD1 | MAT2A | ENSANAP00000019431 | ENSANAP00000023101 | S-adenosylmethionine decarboxylase proenzyme. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.925 |
| AMD1 | MAT2B | ENSANAP00000019431 | ENSANAP00000041478 | S-adenosylmethionine decarboxylase proenzyme. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.868 |
| AMD1 | TAT | ENSANAP00000019431 | ENSANAP00000008551 | S-adenosylmethionine decarboxylase proenzyme. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. | 0.478 |
| BHMT | LOC105707196 | ENSANAP00000011250 | ENSANAP00000017605 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.789 |
| BHMT | LOC105734258 | ENSANAP00000011250 | ENSANAP00000036735 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.903 |
| BHMT | MAT1A | ENSANAP00000011250 | ENSANAP00000007520 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.941 |
| BHMT | MAT2A | ENSANAP00000011250 | ENSANAP00000023101 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.940 |
| BHMT | MAT2B | ENSANAP00000011250 | ENSANAP00000041478 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.903 |
| BHMT | MTHFR | ENSANAP00000011250 | ENSANAP00000036206 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.973 |
| BHMT | MTR | ENSANAP00000011250 | ENSANAP00000038784 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.949 |
| BHMT | TAT | ENSANAP00000011250 | ENSANAP00000008551 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. | 0.925 |
| DNMT3A | LOC105707196 | ENSANAP00000033837 | ENSANAP00000017605 | Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.623 |
| DNMT3A | LOC105734258 | ENSANAP00000033837 | ENSANAP00000036735 | Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.870 |
| DNMT3A | MAT1A | ENSANAP00000033837 | ENSANAP00000007520 | Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.906 |
| DNMT3A | MAT2A | ENSANAP00000033837 | ENSANAP00000023101 | Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.909 |
| DNMT3A | MAT2B | ENSANAP00000033837 | ENSANAP00000041478 | Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.870 |
| LOC105707196 | AMD1 | ENSANAP00000017605 | ENSANAP00000019431 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | S-adenosylmethionine decarboxylase proenzyme. | 0.695 |