Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)    
Predicted Functional Partners:
PIDD1
P53-induced death domain protein 1.
    
 0.996
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain.
    
 0.981
BID
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
    
 0.978
CASP3
Caspase 3; Belongs to the peptidase C14A family.
    
 0.895
ENSANAP00000025464
CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.
    
 0.895
CASP8
Caspase 8; Belongs to the peptidase C14A family.
   
 0.876
APAF1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
    
 0.865
BIRC2
Baculoviral IAP repeat containing 2.
   
 0.826
CASP10
Caspase 10; Belongs to the peptidase C14A family.
   
 0.809
YWHAG
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family.
    
  0.797
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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