HMGCL protein (Aotus nancymaae) - STRING interaction network

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Score

HMGCL

3-hydroxy-3-methylglutaryl-CoA lyase. (374 aa)

Predicted Functional Partners:

BDH1

0.957

HMGCS2

0.957

ACAA1

0.954

AUH

0.950

ACAT2

0.944

HADHB

0.943

ACAA2

0.943

ENSANAP00000000241

0.937

OXCT1

0.937

BCAT2

0.935

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ACAA2	ENSANAP00000011695	ENSANAP00000031914	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.918
ACAA1	ACAT2	ENSANAP00000011695	ENSANAP00000025661	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.922
ACAA1	AUH	ENSANAP00000011695	ENSANAP00000007202	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	AU RNA binding methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.859
ACAA1	ENSANAP00000000241	ENSANAP00000011695	ENSANAP00000000241	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.868
ACAA1	HADHB	ENSANAP00000011695	ENSANAP00000020051	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.918
ACAA1	HMGCL	ENSANAP00000011695	ENSANAP00000010256	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.954
ACAA1	HMGCS2	ENSANAP00000011695	ENSANAP00000022063	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.992
ACAA1	OXCT1	ENSANAP00000011695	ENSANAP00000017248	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.868
ACAA2	ACAA1	ENSANAP00000031914	ENSANAP00000011695	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.918
ACAA2	ACAT2	ENSANAP00000031914	ENSANAP00000025661	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.921
ACAA2	AUH	ENSANAP00000031914	ENSANAP00000007202	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	AU RNA binding methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.787
ACAA2	ENSANAP00000000241	ENSANAP00000031914	ENSANAP00000000241	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.868
ACAA2	HADHB	ENSANAP00000031914	ENSANAP00000020051	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.972
ACAA2	HMGCL	ENSANAP00000031914	ENSANAP00000010256	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.943
ACAA2	HMGCS2	ENSANAP00000031914	ENSANAP00000022063	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.994
ACAA2	OXCT1	ENSANAP00000031914	ENSANAP00000017248	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.868
ACAT2	ACAA1	ENSANAP00000025661	ENSANAP00000011695	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.922
ACAT2	ACAA2	ENSANAP00000025661	ENSANAP00000031914	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.921
ACAT2	AUH	ENSANAP00000025661	ENSANAP00000007202	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	AU RNA binding methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.787
ACAT2	ENSANAP00000000241	ENSANAP00000025661	ENSANAP00000000241	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.920