APLP2 protein (Aotus nancymaae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

APLP2

Amyloid beta precursor like protein 2. (760 aa)

Predicted Functional Partners:

APP

0.980

APBB1

0.946

APBB2

0.913

SORL1

0.905

TTR

0.882

ENSANAP00000010958

0.865

APOE

0.848

PRNP

0.847

SNCA

0.836

APBB3

0.828

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB1	APBB2	ENSANAP00000023284	ENSANAP00000026097	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein binding family B member 2.	0.924
APBB1	APLP2	ENSANAP00000023284	ENSANAP00000010258	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor like protein 2.	0.946
APBB1	APP	ENSANAP00000023284	ENSANAP00000006013	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein.	0.996
APBB1	ENSANAP00000010958	ENSANAP00000023284	ENSANAP00000010958	Amyloid beta precursor protein binding family B member 1.	Uncharacterized protein.	0.851
APBB2	APBB1	ENSANAP00000026097	ENSANAP00000023284	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family B member 1.	0.924
APBB2	APLP2	ENSANAP00000026097	ENSANAP00000010258	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor like protein 2.	0.913
APBB2	APP	ENSANAP00000026097	ENSANAP00000006013	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein.	0.938
APBB3	APLP2	ENSANAP00000033491	ENSANAP00000010258	Amyloid beta precursor protein binding family B member 3.	Amyloid beta precursor like protein 2.	0.828
APBB3	APP	ENSANAP00000033491	ENSANAP00000006013	Amyloid beta precursor protein binding family B member 3.	Amyloid beta precursor protein.	0.932
APBB3	ENSANAP00000010958	ENSANAP00000033491	ENSANAP00000010958	Amyloid beta precursor protein binding family B member 3.	Uncharacterized protein.	0.608
APLP2	APBB1	ENSANAP00000010258	ENSANAP00000023284	Amyloid beta precursor like protein 2.	Amyloid beta precursor protein binding family B member 1.	0.946
APLP2	APBB2	ENSANAP00000010258	ENSANAP00000026097	Amyloid beta precursor like protein 2.	Amyloid beta precursor protein binding family B member 2.	0.913
APLP2	APBB3	ENSANAP00000010258	ENSANAP00000033491	Amyloid beta precursor like protein 2.	Amyloid beta precursor protein binding family B member 3.	0.828
APLP2	APOE	ENSANAP00000010258	ENSANAP00000021488	Amyloid beta precursor like protein 2.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.848
APLP2	APP	ENSANAP00000010258	ENSANAP00000006013	Amyloid beta precursor like protein 2.	Amyloid beta precursor protein.	0.980
APLP2	ENSANAP00000010958	ENSANAP00000010258	ENSANAP00000010958	Amyloid beta precursor like protein 2.	Uncharacterized protein.	0.865
APLP2	PRNP	ENSANAP00000010258	ENSANAP00000025706	Amyloid beta precursor like protein 2.	Major prion protein; Belongs to the prion family.	0.847
APLP2	SNCA	ENSANAP00000010258	ENSANAP00000006994	Amyloid beta precursor like protein 2.	Alpha-synuclein; Belongs to the synuclein family.	0.836
APLP2	SORL1	ENSANAP00000010258	ENSANAP00000027259	Amyloid beta precursor like protein 2.	Sortilin related receptor 1.	0.905
APLP2	TTR	ENSANAP00000010258	ENSANAP00000021419	Amyloid beta precursor like protein 2.	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.	0.882