node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTBP1 | CTBP2 | ENSANAP00000020062 | ENSANAP00000011739 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | C-terminal binding protein 2. | 0.985 |
CTBP1 | ENSANAP00000004461 | ENSANAP00000020062 | ENSANAP00000004461 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.985 |
CTBP1 | HDAC1 | ENSANAP00000020062 | ENSANAP00000009897 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.986 |
CTBP1 | HDAC2 | ENSANAP00000020062 | ENSANAP00000034090 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.985 |
CTBP1 | KDM1A | ENSANAP00000020062 | ENSANAP00000016984 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.935 |
CTBP1 | MECOM | ENSANAP00000020062 | ENSANAP00000013395 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | MDS1 and EVI1 complex locus. | 0.972 |
CTBP1 | RBPJ | ENSANAP00000020062 | ENSANAP00000022232 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Recombination signal binding protein for immunoglobulin kappa J region. | 0.926 |
CTBP1 | RBPJL | ENSANAP00000020062 | ENSANAP00000007385 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Recombination signal binding protein for immunoglobulin kappa J region like. | 0.925 |
CTBP1 | RUNX1 | ENSANAP00000020062 | ENSANAP00000024288 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.927 |
CTBP1 | TCF7 | ENSANAP00000020062 | ENSANAP00000032444 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Transcription factor 7. | 0.929 |
CTBP2 | CTBP1 | ENSANAP00000011739 | ENSANAP00000020062 | C-terminal binding protein 2. | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.985 |
CTBP2 | HDAC1 | ENSANAP00000011739 | ENSANAP00000009897 | C-terminal binding protein 2. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.889 |
CTBP2 | HDAC2 | ENSANAP00000011739 | ENSANAP00000034090 | C-terminal binding protein 2. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.888 |
CTBP2 | KDM1A | ENSANAP00000011739 | ENSANAP00000016984 | C-terminal binding protein 2. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.788 |
CTBP2 | MECOM | ENSANAP00000011739 | ENSANAP00000013395 | C-terminal binding protein 2. | MDS1 and EVI1 complex locus. | 0.918 |
CTBP2 | RBPJ | ENSANAP00000011739 | ENSANAP00000022232 | C-terminal binding protein 2. | Recombination signal binding protein for immunoglobulin kappa J region. | 0.895 |
CTBP2 | RBPJL | ENSANAP00000011739 | ENSANAP00000007385 | C-terminal binding protein 2. | Recombination signal binding protein for immunoglobulin kappa J region like. | 0.895 |
CTBP2 | RUNX1 | ENSANAP00000011739 | ENSANAP00000024288 | C-terminal binding protein 2. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.879 |
CTBP2 | TCF7 | ENSANAP00000011739 | ENSANAP00000032444 | C-terminal binding protein 2. | Transcription factor 7. | 0.891 |
ENSANAP00000004461 | CTBP1 | ENSANAP00000004461 | ENSANAP00000020062 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.985 |