node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | ERBB3 | ENSANAP00000037076 | ENSANAP00000015882 | Epidermal growth factor receptor. | Erb-b2 receptor tyrosine kinase 3. | 0.993 |
EGFR | HGF | ENSANAP00000037076 | ENSANAP00000021854 | Epidermal growth factor receptor. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.883 |
EGFR | IGF1 | ENSANAP00000037076 | ENSANAP00000010334 | Epidermal growth factor receptor. | Insulin like growth factor 1. | 0.951 |
EGFR | MET | ENSANAP00000037076 | ENSANAP00000009807 | Epidermal growth factor receptor. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.968 |
EGFR | MST1R | ENSANAP00000037076 | ENSANAP00000017891 | Epidermal growth factor receptor. | Macrophage stimulating 1 receptor. | 0.941 |
EGFR | NTRK1 | ENSANAP00000037076 | ENSANAP00000027419 | Epidermal growth factor receptor. | Tyrosine-protein kinase receptor. | 0.450 |
EGFR | PDGFB | ENSANAP00000037076 | ENSANAP00000037415 | Epidermal growth factor receptor. | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.930 |
EGFR | VEGFA | ENSANAP00000037076 | ENSANAP00000007661 | Epidermal growth factor receptor. | Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. | 0.843 |
EGFR | VEGFC | ENSANAP00000037076 | ENSANAP00000038004 | Epidermal growth factor receptor. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.791 |
EGFR | VEGFD | ENSANAP00000037076 | ENSANAP00000041845 | Epidermal growth factor receptor. | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. | 0.811 |
ERBB3 | EGFR | ENSANAP00000015882 | ENSANAP00000037076 | Erb-b2 receptor tyrosine kinase 3. | Epidermal growth factor receptor. | 0.993 |
ERBB3 | HGF | ENSANAP00000015882 | ENSANAP00000021854 | Erb-b2 receptor tyrosine kinase 3. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.890 |
ERBB3 | IGF1 | ENSANAP00000015882 | ENSANAP00000010334 | Erb-b2 receptor tyrosine kinase 3. | Insulin like growth factor 1. | 0.793 |
ERBB3 | MET | ENSANAP00000015882 | ENSANAP00000009807 | Erb-b2 receptor tyrosine kinase 3. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.976 |
ERBB3 | MST1R | ENSANAP00000015882 | ENSANAP00000017891 | Erb-b2 receptor tyrosine kinase 3. | Macrophage stimulating 1 receptor. | 0.927 |
ERBB3 | NTRK1 | ENSANAP00000015882 | ENSANAP00000027419 | Erb-b2 receptor tyrosine kinase 3. | Tyrosine-protein kinase receptor. | 0.417 |
ERBB3 | PDGFB | ENSANAP00000015882 | ENSANAP00000037415 | Erb-b2 receptor tyrosine kinase 3. | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.899 |
ERBB3 | VEGFA | ENSANAP00000015882 | ENSANAP00000007661 | Erb-b2 receptor tyrosine kinase 3. | Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. | 0.822 |
ERBB3 | VEGFC | ENSANAP00000015882 | ENSANAP00000038004 | Erb-b2 receptor tyrosine kinase 3. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.765 |
ERBB3 | VEGFD | ENSANAP00000015882 | ENSANAP00000041845 | Erb-b2 receptor tyrosine kinase 3. | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. | 0.772 |