DYRK3 protein (Aotus nancymaae) - STRING interaction network

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Score

DYRK3

Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa)

Predicted Functional Partners:

ENSANAP00000011966

0.803

ATM

0.602

DCAF1

0.559

PLK1

0.550

PLK2

0.550

PLK3

0.550

PLK4

0.529

PIN1

0.504

MECP2

0.480

LOC105711962

0.448

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	DYRK3	ENSANAP00000011320	ENSANAP00000041165	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.602
ATM	LOC105711962	ENSANAP00000011320	ENSANAP00000018725	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MDM2 proto-oncogene.	0.803
DCAF1	DYRK3	ENSANAP00000026236	ENSANAP00000041165	DDB1 and CUL4 associated factor 1.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.559
DYRK3	ATM	ENSANAP00000041165	ENSANAP00000011320	Dual specificity tyrosine phosphorylation regulated kinase 3.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.602
DYRK3	DCAF1	ENSANAP00000041165	ENSANAP00000026236	Dual specificity tyrosine phosphorylation regulated kinase 3.	DDB1 and CUL4 associated factor 1.	0.559
DYRK3	ENSANAP00000011966	ENSANAP00000041165	ENSANAP00000011966	Dual specificity tyrosine phosphorylation regulated kinase 3.	WD_REPEATS_REGION domain-containing protein.	0.803
DYRK3	LOC105711962	ENSANAP00000041165	ENSANAP00000018725	Dual specificity tyrosine phosphorylation regulated kinase 3.	MDM2 proto-oncogene.	0.448
DYRK3	MECP2	ENSANAP00000041165	ENSANAP00000003548	Dual specificity tyrosine phosphorylation regulated kinase 3.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.480
DYRK3	PIN1	ENSANAP00000041165	ENSANAP00000005879	Dual specificity tyrosine phosphorylation regulated kinase 3.	Peptidyl-prolyl cis-trans isomerase.	0.504
DYRK3	PLK1	ENSANAP00000041165	ENSANAP00000016212	Dual specificity tyrosine phosphorylation regulated kinase 3.	Serine/threonine-protein kinase PLK.	0.550
DYRK3	PLK2	ENSANAP00000041165	ENSANAP00000027594	Dual specificity tyrosine phosphorylation regulated kinase 3.	Serine/threonine-protein kinase PLK.	0.550
DYRK3	PLK3	ENSANAP00000041165	ENSANAP00000028058	Dual specificity tyrosine phosphorylation regulated kinase 3.	Polo like kinase 3.	0.550
DYRK3	PLK4	ENSANAP00000041165	ENSANAP00000030791	Dual specificity tyrosine phosphorylation regulated kinase 3.	Polo like kinase 4.	0.529
ENSANAP00000011966	DYRK3	ENSANAP00000011966	ENSANAP00000041165	WD_REPEATS_REGION domain-containing protein.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.803
LOC105711962	ATM	ENSANAP00000018725	ENSANAP00000011320	MDM2 proto-oncogene.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.803
LOC105711962	DYRK3	ENSANAP00000018725	ENSANAP00000041165	MDM2 proto-oncogene.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.448
MECP2	DYRK3	ENSANAP00000003548	ENSANAP00000041165	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.480
PIN1	DYRK3	ENSANAP00000005879	ENSANAP00000041165	Peptidyl-prolyl cis-trans isomerase.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.504
PIN1	PLK1	ENSANAP00000005879	ENSANAP00000016212	Peptidyl-prolyl cis-trans isomerase.	Serine/threonine-protein kinase PLK.	0.432
PLK1	DYRK3	ENSANAP00000016212	ENSANAP00000041165	Serine/threonine-protein kinase PLK.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.550