Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (324 aa)    
Predicted Functional Partners:
hprT
Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthin; has very low activity towards guanine. Inactive towards xanthine (By similarity); Belongs to the purine/pyrimidine phosphoribosyltransferase family; KEGG: nfa:nfa3890 hypoxanthine phosphoribosyltransferase.
 
  
 0.975
dacB
Hypothetical protein.
 
   
 0.887
APA94431.1
Hypothetical protein.
     
 0.886
pheT
Phenylalanine--tRNA ligase; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily; Contains 1 B5 domain; Contains 1 FDX-ACB domain; Contains 1 tRNA-binding domain; KEGG: asd:AS9A_1504 phenylalanyl-tRNA synthetase beta chain.
 
  
 0.814
pth1
Aminoacyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
  
  
 0.749
mfd
Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
 
  
 0.743
karS
Lysine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family; KEGG: ckp:ckrop_1644 lysyl-tRNA synthetase, class II.
   
 
 0.717
truA
tRNA pseudouridine(38-40) synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
 
  
 0.715
lysS
Lysine--tRNA ligase; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M. tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine resu [...]
   
 
 0.711
ppa
Inorganic diphosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
     
 0.699
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: medium (44%) [HD]
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