| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APA94431.1 | dacB | NS506_00347 | NS506_00348 | Hypothetical protein. | Hypothetical protein. | 0.959 |
| APA94431.1 | hprT | NS506_00347 | NS506_00345 | Hypothetical protein. | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthin; has very low activity towards guanine. Inactive towards xanthine (By similarity); Belongs to the purine/pyrimidine phosphoribosyltransferase family; KEGG: nfa:nfa3890 hypoxanthine phosphoribosyltransferase. | 0.871 |
| APA94431.1 | ppa | NS506_00347 | NS506_00349 | Hypothetical protein. | Inorganic diphosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. | 0.734 |
| APA94431.1 | tilS | NS506_00347 | NS506_00346 | Hypothetical protein. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.904 |
| dacB | APA94431.1 | NS506_00348 | NS506_00347 | Hypothetical protein. | Hypothetical protein. | 0.959 |
| dacB | hprT | NS506_00348 | NS506_00345 | Hypothetical protein. | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthin; has very low activity towards guanine. Inactive towards xanthine (By similarity); Belongs to the purine/pyrimidine phosphoribosyltransferase family; KEGG: nfa:nfa3890 hypoxanthine phosphoribosyltransferase. | 0.828 |
| dacB | ppa | NS506_00348 | NS506_00349 | Hypothetical protein. | Inorganic diphosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. | 0.740 |
| dacB | tilS | NS506_00348 | NS506_00346 | Hypothetical protein. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.904 |
| hprT | APA94431.1 | NS506_00345 | NS506_00347 | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthin; has very low activity towards guanine. Inactive towards xanthine (By similarity); Belongs to the purine/pyrimidine phosphoribosyltransferase family; KEGG: nfa:nfa3890 hypoxanthine phosphoribosyltransferase. | Hypothetical protein. | 0.871 |
| hprT | dacB | NS506_00345 | NS506_00348 | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthin; has very low activity towards guanine. Inactive towards xanthine (By similarity); Belongs to the purine/pyrimidine phosphoribosyltransferase family; KEGG: nfa:nfa3890 hypoxanthine phosphoribosyltransferase. | Hypothetical protein. | 0.828 |
| hprT | ppa | NS506_00345 | NS506_00349 | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthin; has very low activity towards guanine. Inactive towards xanthine (By similarity); Belongs to the purine/pyrimidine phosphoribosyltransferase family; KEGG: nfa:nfa3890 hypoxanthine phosphoribosyltransferase. | Inorganic diphosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. | 0.637 |
| hprT | tilS | NS506_00345 | NS506_00346 | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthin; has very low activity towards guanine. Inactive towards xanthine (By similarity); Belongs to the purine/pyrimidine phosphoribosyltransferase family; KEGG: nfa:nfa3890 hypoxanthine phosphoribosyltransferase. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.982 |
| iarS | lysS | NS506_03364 | NS506_00681 | Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. | Lysine--tRNA ligase; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M. tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine resu [...] | 0.900 |
| iarS | pheT | NS506_03364 | NS506_03626 | Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. | Phenylalanine--tRNA ligase; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily; Contains 1 B5 domain; Contains 1 FDX-ACB domain; Contains 1 tRNA-binding domain; KEGG: asd:AS9A_1504 phenylalanyl-tRNA synthetase beta chain. | 0.981 |
| iarS | tilS | NS506_03364 | NS506_00346 | Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.791 |
| lysS | iarS | NS506_00681 | NS506_03364 | Lysine--tRNA ligase; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M. tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine resu [...] | Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. | 0.900 |
| lysS | pheT | NS506_00681 | NS506_03626 | Lysine--tRNA ligase; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M. tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine resu [...] | Phenylalanine--tRNA ligase; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily; Contains 1 B5 domain; Contains 1 FDX-ACB domain; Contains 1 tRNA-binding domain; KEGG: asd:AS9A_1504 phenylalanyl-tRNA synthetase beta chain. | 0.823 |
| lysS | tilS | NS506_00681 | NS506_00346 | Lysine--tRNA ligase; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M. tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine resu [...] | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.681 |
| mfd | pth1 | NS506_01669 | NS506_01650 | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | Aminoacyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.739 |
| mfd | tilS | NS506_01669 | NS506_00346 | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.706 |
STRING v12.5 is now available!
