STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
acsSAcetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family; KEGG: nno:NONO_c03820 acetyl-CoA synthetase. (650 aa)    
Predicted Functional Partners:
gltA
Citrate (Si)-synthase; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield (2S,3S)-2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl- CoA; Belongs to the citrate synthase family; KEGG: rpm:RSPPHO_02006 citrate synthase.
  
 0.951
APB01799.1
Belongs to the citrate synthase family; KEGG: nbr:O3I_003710 citrate synthase.
  
 0.951
APB01796.1
Belongs to the citrate synthase family; KEGG: rhb:NY08_2544 citrate synthase.
  
 0.947
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
   
 
 0.945
aceB
Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
  
 0.945
APA95237.1
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.935
APA94504.1
Aldehyde dehydrogenase (NAD(+)); 2-hydroxymuconic acid semialdehyde can be converted to 2-hydroxypent-2,4-dienoate either directly by the action of 2- hydroxymuconic semialdehyde hydrolase (HMSH) or by the action of three sequential enzymes, the first of which is HMSD. Belongs to the aldehyde dehydrogenase family; KEGG: mtu:Rv0768 aldehyde dehydrogenase (NAD+).
  
 0.932
APA95114.1
Belongs to the aldehyde dehydrogenase family; KEGG: nfa:nfa54770 aldehyde dehydrogenase (NAD+).
  
 0.932
aldB
Belongs to the aldehyde dehydrogenase family; KEGG: mad:HP15_3144 aldehyde dehydrogenase; With NAD(+) or NADP(+) as acceptor.
  
 0.932
APA98655.1
Belongs to the aldehyde dehydrogenase family; KEGG: eam:EAMY_2114 aldehyde dehydrogenase; With NAD(+) or NADP(+) as acceptor.
  
 0.932
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.