STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (600 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.986
leuC
3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.986
mhpF
Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
  
 0.979
APA97299.1
Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family; KEGG: nno:NONO_c22830 branched-chain amino acid aminotransferase.
  
 0.975
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family; KEGG: mgi:Mflv_5171 dihydroxy-acid dehydratase.
  
 
 0.967
ilvD-2
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family; KEGG: myv:G155_10260 dihydroxy-acid dehydratase.
  
 
 0.967
ilvH
Belongs to the acetolactate synthase small subunit family; Contains 1 ACT domain; KEGG: mgi:Mflv_4238 acetolactate synthase I/III small subunit.
 
 
 0.954
ilvB
Acetolactate synthase; Belongs to the TPP enzyme family; KEGG: nfa:nfa42320 acetolactate synthase I/II/III large subunit.
 
 
 0.953
bccA
Acetyl-CoA carboxylase; This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase; Contains 1 ATP-grasp domain; Contains 1 biotin carboxylation domain; Contains 1 biotinyl-binding domain; KEGG: ncy:NOCYR_4821 acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein.
  
 
 0.938
APB01318.1
Acetyl-CoA carboxylase; Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism; Contains 1 ATP-grasp domain; Contains 1 biotin carboxylation domain; Contains 1 biotinyl-binding domain; KEGG: ncy:NOCYR_1052 acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein.
  
 
 0.938
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.