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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APA95409.1Histidine kinase; Member of the two-component regulatory system SphR/SphS. Sensory kinase. Is involved in inducible production of alkaline phosphatase in response to phosphate limitation as it is directly involved in the regulation of phoA transcription in response to phosphate limitation. SphS functions as a protein kinase that phosphorylates SphR. Contains 1 histidine kinase domain; Contains 1 PAS (PER-ARNT-SIM) domain; KEGG: nbr:O3I_034475 two-component system, OmpR family, sensor kinase. (484 aa)    
Predicted Functional Partners:
APA95408.1
CAI-1 autoinducer sensor kinase/phosphatase CqsS; Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO; Contains 1 histidine kinase domain; Contains 1 response regulatory domain.
 
 0.975
APA98486.1
Member of the two-component regulatory system GlrR/GlrK that up-regulates transcription of the glmY sRNA when cells enter the stationary growth phase. Regulates glmY transcription by binding to three conserved sites in the purL-glmY intergenic region; Contains 1 response regulatory domain; Contains 1 sigma-54 factor interaction domain.
 
 0.877
APA99024.1
Response regulator MprA; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity); Contains 1 OmpR/PhoB-type DNA-binding domain; Contains 1 response regulatory domain.
 
 0.877
APA98011.1
Putative transcriptional regulatory protein TcrX; Member of the two-component regulatory system TcrY/TcrX; Contains 1 OmpR/PhoB-type DNA-binding domain; Contains 1 response regulatory domain.
 
 0.864
evgS
Histidine kinase; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals (By similarity); Contains 1 histidine kinase domain; Contains 1 HPt domain; Contains 1 response regulatory domain; KEGG: eco:b2370 two-component system, NarL family, sensor histidine kinase EvgS; overlaps another CDS with the same product name.
 
 0.862
rcsC
Histidine kinase; Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions (By similarity); Contains 1 OmpR/PhoB-type DNA-binding domain; Contains 1 response regulatory domain; KEGG: kmi:VW41_15445 two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC; overlaps another CDS with the same product name.
 
 0.855
barA
Histidine kinase; Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon; Contains 1 OmpR/PhoB-type DNA-binding domain; Contains 1 response regulatory domain; KEGG: gpb:HDN1F_09420 two-component system, NarL family, sensor histidine kinase BarA.
 
 
 0.854
APA94242.1
Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism. Contains 1 OmpR/PhoB-type DNA-binding domain; Contains 1 response regulatory domain.
 
 0.852
APA96152.1
Chemotaxis response regulator protein-glutamate methylesterase; Involved in the modulation of the chemotaxis syste; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR; Contains 1 cheB-type methylesterase domain; Contains 1 response regulatory domain.
 
 0.845
APA96511.1
Response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR; Contains 1 OmpR/PhoB-type DNA-binding domain; Contains 1 response regulatory domain.
 
 0.841
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (34%) [HD]
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