close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APA95532.1HTH-type transcriptional repressor KstR2; Controls the expression of a small regulon that may play a role in the utilization of cholesterol; Contains 1 HTH tetR-type DNA-binding domain. (227 aa)    
Predicted Functional Partners:
APA95529.1
Hypothetical protein.
 
     0.781
APA95528.1
Hypothetical protein.
 
     0.693
APA95527.1
Urea carboxylase; Involved in uracil catabolism. Hydrolysis of urea to ammonia and CO(2); Belongs to the DUR1,2 family; Contains 1 ATP-grasp domain; Contains 1 biotin carboxylation domain; Contains 1 biotinyl-binding domain; KEGG: spe:Spro_1419 urea carboxylase.
 
 
 
 0.678
APA95531.1
Thiamine transporter involved in the cellular uptake of thiamine. Pyrithiamine, oxythiamine, amprolium, and the thiazole part of thiamine have been shown to be also substrates of thi9; Belongs to the amino acid-polyamine-organocation (APC) superfamily.
 
     0.637
atzF
Allophanate hydrolase; Belongs to the amidase family; KEGG: mab:MAB_1558c allophanate hydrolase.
 
     0.585
APB00496.1
Nitrogen regulatory protein P-II; In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P- II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P- II-UMP, these events are reversed (By similarity); Be [...]
     
 0.532
APA95530.1
Hypothetical protein.
       0.487
APA96330.1
HTH-type transcriptional repressor AcnR; AcnR negatively controls the expression of the aconitase gene acn; Contains 1 HTH tetR-type DNA-binding domain.
  
     0.475
APA95353.1
HTH-type transcriptional repressor KstR2; Controls the expression of a small regulon that may play a role in the utilization of cholesterol; Contains 1 HTH tetR-type DNA-binding domain.
  
     0.465
APA99034.1
HTH-type transcriptional repressor KstR; Controls the expression of genes used for utilizing diverse lipids as energy sources; Contains 1 HTH tetR-type DNA-binding domain.
  
   
 0.424
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.