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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APA95816.1Succinate dehydrogenase (quinone); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily; KEGG: red:roselon_01721 succinate dehydrogenase / fumarate reductase, flavoprotein subunit; overlaps another CDS with the same product name. (634 aa)    
Predicted Functional Partners:
APA95815.1
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family; Contains 1 2Fe-2S ferredoxin-type domain; Contains 1 4Fe-4S ferredoxin-type domain; KEGG: mtu:Rv0247c succinate dehydrogenase / fumarate reductase, iron-sulfur subunit; overlaps another CDS with the same product name.
 
 0.991
APA95817.1
Hypothetical protein.
 
 
 
 0.968
sdhB
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family; Contains 1 2Fe-2S ferredoxin-type domain; Contains 1 4Fe-4S ferredoxin-type domain; KEGG: nfa:nfa56030 succinate dehydrogenase / fumarate reductase, iron-sulfur subunit.
 
 0.965
APB01371.1
Succinate dehydrogenase (quinone); Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S- S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen; Contains 1 2Fe-2S ferredoxin-type domain; Contains 2 4Fe-4S ferredoxin-type domains; KEGG: nno:NONO_c11110 succinate dehydrogenase / fuma [...]
 
 0.944
fumA
Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.924
sdhC
Membrane-anchoring subunit of succinate dehydrogenase 2 (Sdh2). Sdh2 may catalyze the two-electron oxidation of succinate to fumarate with a corresponding reduction of quinone to quinol under low oxygen conditions, when the primary aerobic succinate dehydrogenase (Sdh1) is inhibited. Sdh2 seems to be the generator of the proton motive force (PMF) under hypoxia; Belongs to the cytochrome b560 family.
  
 0.920
sucC
Succinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.919
APB01369.1
Hypothetical protein.
  
 
 0.903
mtkB
Malate--CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.902
aspA
Aspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
 
 0.871
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: medium (42%) [HD]
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