STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APA96023.1Histidine kinase; KEGG: pdx:Psed_4463 two-component system, NarL family, sensor histidine kinase DesK. (383 aa)    
Predicted Functional Partners:
cheB
Protein-glutamate methylesterase; Involved in the modulation of the chemotaxis syste; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR; Contains 1 cheB-type methylesterase domain; Contains 1 response regulatory domain; KEGG: gpb:HDN1F_14830 two-component system, chemotaxis family, response regulator CheB.
 
 
 0.917
APA96956.1
Histidine kinase; Member of the two-component regulatory system YvfT/YvfU. Probably activates YvfU by phosphorylation; Contains 1 histidine kinase domain; KEGG: rer:RER_47110 two-component system, NarL family, sensor histidine kinase DesK.
  
     0.728
APA96957.1
Chemotaxis response regulator protein-glutamate methylesterase; Involved in the modulation of the chemotaxis syste; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR; Contains 1 cheB-type methylesterase domain; Contains 1 response regulatory domain.
 
 
 0.720
APA99057.1
Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation, biofilm formation, and competence for DNA uptake. Positively or negatively regulates expression of many different genes. The phosphorylated form is required for synthesis of degradative enzymes, flagellum formation and biofilm formation. The unphosphorylated form is required for expression of [...]
 
 
 0.706
APB00387.1
Protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). Contains 1 response regulatory domain.
 
 
 0.689
APA98909.1
Nitrate/nitrite response regulator protein like protein; Could activate the expression of a formate dehydrogenase operon and could repress the transcription of the fumarate reductase (frdABCD) operon. Contains 1 HTH luxR-type DNA-binding domain; Contains 1 response regulatory domain.
 
 
 0.687
APA95201.1
Putative transcriptional regulatory protein pdtaR; Member of the two-component regulatory system pdtaR/pdtaS; Contains 1 ANTAR domain; Contains 1 response regulatory domain.
 
 
 0.684
APA96852.1
Chemotaxis response regulator protein-glutamate methylesterase; Involved in the modulation of the chemotaxis syste; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR; Contains 1 cheB-type methylesterase domain; Contains 1 response regulatory domain.
 
 
 0.681
APB01429.1
Chemotaxis response regulator protein-glutamate methylesterase of group 1 operon; Involved in the modulation of the chemotaxis syste; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR; Contains 1 cheB-type methylesterase domain; Contains 1 response regulatory domain.
 
 
 0.671
APA94396.1
Stage 0 sporulation protein; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box) (By similarity); Contains 1 response regulatory domain.
 
 
 0.667
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.