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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APA96144.1Histidine kinase; Member of the two-component regulatory system CitT/CitS. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex (By similarity); Contains 1 histidine kinase domain; Contains 1 PAS (PER-ARNT-SIM) domain; KEGG: fre:Franean1_4414 two-component system, CitB family, sensor kinase. (518 aa)    
Predicted Functional Partners:
APA96145.1
Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABC; nuoA; dcu; dcu; sdhCDA; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA (By similarity); Contains 1 response regulatory domain.
 
 
 0.983
APA97452.1
Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions (By similarity); Contains 1 response regulatory domain.
 
 
 0.933
APA96143.1
C4-dicarboxylate transport protein; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane; Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family.
 
  
 0.849
APA99217.1
Uncharacterized protein; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 PPM-type phosphatase domain; Contains 1 STAS domain; KEGG: mmc:Mmcs_0350 null; Phosphotransferases with a nitrogenous group as acceptor.
 
  
 0.424
APA96146.1
Catalyzes the hydroxylation of n-alkanes and fatty acids in the presence of a NADH-rubredoxin reductase and rubredoxin. It preferably hydroxylases C5-C12 hydrocarbons; Belongs to the fatty acid desaturase family. AlkB subfamily; KEGG: nfa:nfa46140 alkane 1-monooxygenase.
       0.423
APA98134.1
Hypothetical protein.
  
     0.411
APA97055.1
C4-dicarboxylate transport protein; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane; Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family.
 
  
 0.405
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: medium (46%) [HD]
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