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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemDKEGG: nfa:nfa45590 uroporphyrinogen-III synthase. (527 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.984
cysG
Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: nbr:O3I_030625 uroporphy [...]
 
 
 0.983
APA94222.1
Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family; KEGG: nfa:nfa51680 uroporphyrinogen III methyltransferase.
 
 
 0.959
nirD
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family; KEGG: nfa:nfa45600 nitrite reductase (NADH) small subunit.
 
  
 0.954
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.950
APA96213.1
Hypothetical protein.
 
  
 0.945
nirB
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family; KEGG: nfa:nfa45610 nitrite reductase (NADH) large subunit.
 
  
 0.913
APA96209.1
Nitrate/nitrite transporter; Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. May function as a nitrate/H(+) and nitrite/H(+) channel. Could confer a selective advantage during severe nutrient starvation or slow growth; Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2. A. 1. 8) family.
 
  
 0.897
hemB
Porphobilinogen synthase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family; KEGG: gni:GNIT_0516 porphobilinogen synthase.
  
 
 0.847
APA96206.1
Nitrate/nitrite transporter; Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. Functions as a nitrate/nitrite exchanger, and protons are probably not co- transported with the substrate; Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2. A. 1. 8) family.
 
  
 0.785
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (32%) [HD]
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