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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APA96422.13,4-dihydroxy-9,10-secoandrosta-1,3, 5(10)-triene-9,17-dione 4,5-dioxygenase; Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10), 2-diene-4- oic acid (4,9-DSHA); Belongs to the extradiol ring-cleavage dioxygenase family; KEGG: reu:Reut_A1557 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9, 17-dione 4,5-dioxygenase; overlaps another CDS with the same product name. (50 aa)    
Predicted Functional Partners:
APA96421.1
3,4-dihydroxy-9,10-secoandrosta-1,3, 5(10)-triene-9,17-dione 4,5-dioxygenase; Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10), 2-diene-4- oic acid (4,9-DSHA); Belongs to the extradiol ring-cleavage dioxygenase family; KEGG: msm:MSMEG_6036 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9, 17-dione 4,5-dioxygenase; overlaps another CDS with the same product name.
 
     0.946
hsaD
4,5-9,10-diseco-3-hydroxy-5,9, 17-trioxoandrosta-1(10),2-diene-4-oatehydrolase; Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10), 2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5- oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Also involved in biphenyl and polychlorinated biphenyls (PCBs) degradation; Belongs to the AB hydrolase superfamily. HsaD family; KEGG: rpy:Y013_19030 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10), 2-diene-4-oate hydrolase.
 
  
 0.909
APA98374.1
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9, 17-dione monooxygenase; Catalyzes the o-hydroxylation of 3-hydroxy-9,10- secoandrosta-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol; Belongs to the HpaH/HsaA monooxygenase family; KEGG: nar:Saro_3648 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.
 
  
 0.896
hsaA
KEGG: nfa:nfa4740 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.
 
  
 0.894
APA98748.1
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9, 17-dione monooxygenase; Catalyzes the o-hydroxylation of 3-hydroxy-9,10- secoandrosta-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Can use either FADH(2) or FMNH(2) as flavin cosubstrate. Also catalyzes the o-hydroxylation of a range of p-substituted phenols to generate the corresponding catechols (By similarity); Belongs to the HpaH/HsaA monooxygenase family; KEGG: salu:DC74_7445 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione mono [...]
 
  
 0.889
APA98898.1
KEGG: nfa:nfa33590 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.
 
  
 0.875
kshA
3-ketosteroid 9-alpha-monooxygenase; Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage; Contains 1 Rieske domain; KEGG: nfa:nfa4750 3-ketosteroid 9alpha-monooxygenase subunit A.
 
   
 0.853
APA98373.1
3-ketosteroid 9-alpha-monooxygenase; Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage; Contains 1 Rieske domain; KEGG: nfa:nfa33740 3-ketosteroid 9alpha-monooxygenase subunit A.
 
   
 0.853
APB00812.1
3-ketosteroid 9-alpha-monooxygenase; Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage; Contains 1 Rieske domain; KEGG: mne:D174_24200 3-ketosteroid 9alpha-monooxygenase subunit A.
 
   
 0.853
APB00322.1
3-ketosteroid 9-alpha-monooxygenase; Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage; Contains 1 Rieske domain; KEGG: asd:AS9A_0922 3-ketosteroid 9alpha-monooxygenase subunit A.
 
   
 0.852
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
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