close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APA97497.1Transcriptional regulatory protein; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin (By similarity); Contains 1 OmpR/PhoB-type DNA-binding domain; Contains 1 response regulatory domain. (222 aa)    
Predicted Functional Partners:
APA97498.1
Histidine kinase; KEGG: sals:SLNWT_5081 two-component system, OmpR family, sensor kinase.
 
 
 0.963
APA97482.1
Nitrogen assimilation regulatory protein; Member of the two-component regulatory system NtrB/NtrC involved in the activation of nitrogen assimilatory genes such as GlnA. NtrC is phosphorylated by NtrB and interacts with sigma-54. Contains 1 response regulatory domain; Contains 1 sigma-54 factor interaction domain.
  
  
 
0.904
APB00724.1
Response regulator MprA; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity). MprB/MprA up-regulates expression of mprA and pepD; Contains 1 OmpR/PhoB-type DNA-binding domain; Contains 1 response regulat [...]
  
  
 
0.901
APB00726.1
Histidine kinase; KEGG: sals:SLNWT_5081 two-component system, OmpR family, sensor kinase.
 
 
 0.850
APA97138.1
Histidine kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: nbr:O3I_033100 [...]
 
 
 0.845
phoR
Histidine kinase; Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: tao:THIAE_02250 two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR.
 
 
 0.838
APA96782.1
Histidine kinase; Member of the three-protein two-component system HK1/HK2/TcrA. HK2 transfers its phosphoryl group to TcrA; Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: rme:Rmet_5332 two-component system, OmpR family, sensor kinase.
 
 
 0.832
APA99575.1
Histidine kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: svl:Strvi_5994 [...]
 
 
 0.832
prrB
Histidine kinase; Member of the two-component regulatory system PrrB/PrrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates PrrA (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: req:REQ_12240 two-component system, OmpR family, sensor histidine kinase PrrB.
 
 
 0.831
cusS
Histidine kinase; Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: gpb:HDN1F_00420 two-component system, OmpR family, heavy metal sensor histidine kinase CusS.
 
 
 0.821
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.