STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APA97654.1Hypoxia sensor histidine kinase response regulator DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor; the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR) (By similarity); Contains 2 GAF domains; Contains 1 histidine kinase domain; KEGG: mmc:Mmcs_1077 null; Phosphotransferases with a nitrogenous group as acceptor. (577 aa)    
Predicted Functional Partners:
APA97655.1
Transcriptional regulatory protein DevR (DosR); Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response; Contains 1 HTH luxR-type DNA-binding domain; Contains 1 response regulatory domain.
 
 
 0.921
APA98387.1
Uncharacterized protein; ATP-binding; Cell wall; Nucleotide-binding; Secreted.
  
    0.892
APA99217.1
Uncharacterized protein; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 PPM-type phosphatase domain; Contains 1 STAS domain; KEGG: mmc:Mmcs_0350 null; Phosphotransferases with a nitrogenous group as acceptor.
 
 
 0.870
APA98389.1
Transcriptional regulatory protein DevR (DosR); Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response; Contains 1 HTH luxR-type DNA-binding domain; Contains 1 response regulatory domain.
 
 
 0.819
APB00927.1
Protein-glutamate methylesterase; Involved in the modulation of the chemotaxis syste; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR; Contains 1 cheB-type methylesterase domain; Contains 1 response regulatory domain; KEGG: xcc:XCC2705 two-component system, chemotaxis family, response regulator CheB.
 
 
 0.705
APA97766.1
Transcriptional regulatory protein DevR (DosR); Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response; Contains 1 HTH luxR-type DNA-binding domain; Contains 1 response regulatory domain.
 
 
 0.673
APA95831.1
Cyclic di-GMP phosphodiesterase response regulator RpfG; Member of the two-component regulatory system RpfG/RpfC, which is required for full virulence and for formation and dispersal of biofilms. Involved in sensing and responding to the diffusible signaling factor (DSF), which is essential for cell- cell signaling. Activated RpfG degrades cyclic di-GMP, an unusual nucleotide second messenger, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in DSF pathway. May also directly control genes involved in biofilm dispersal; Contains 1 [...]
  
 
 0.653
APB00199.1
Putative transcriptional regulatory protein YxjL; Probable member of the two-component regulatory system YxjM/YxjL; Contains 1 HTH luxR-type DNA-binding domain; Contains 1 response regulatory domain.
  
 
 0.653
APB00115.1
Protein-glutamate methylesterase; This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins; Contains 1 HTH luxR-type DNA-binding domain; Contains 1 response regulatory domain; KEGG: cbx:Cenrod_2137 two-component system, chemotaxis family, response regulator CheB.
 
 
 0.643
APA97780.1
Chemotaxis response regulator protein-glutamate methylesterase; Involved in the modulation of the chemotaxis syste; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR; Contains 1 cheB-type methylesterase domain; Contains 1 response regulatory domain.
 
 
 0.618
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.