| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APA96072.1 | APB01298.1 | NS506_02005 | NS506_07278 | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | (S)-2-hydroxy-acid oxidase; Belongs to the FAD-binding oxidoreductase/transferase type 4 family; Contains 1 FAD-binding PCMH-type domain; KEGG: cct:CC1_16380 glycolate oxidase. | 0.922 |
| APA96072.1 | aceA | NS506_02005 | NS506_00197 | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family; KEGG: mab:MAB_4095c isocitrate lyase. | 0.953 |
| APA96072.1 | aceB | NS506_02005 | NS506_05267 | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.951 |
| APA96072.1 | eda | NS506_02005 | NS506_03642 | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | Belongs to the KHG/KDPG aldolase family; KEGG: msm:MSMEG_3788 2-dehydro-3-deoxyphosphogluconate aldolase. | 0.930 |
| APA96072.1 | gap | NS506_02005 | NS506_04154 | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | Belongs to the glyceraldehyde-3-phosphate dehydrogenase family; KEGG: mtu:Rv1436 glyceraldehyde 3-phosphate dehydrogenase. | 0.564 |
| APA96072.1 | gapA | NS506_02005 | NS506_03068 | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | Belongs to the glyceraldehyde-3-phosphate dehydrogenase family; KEGG: pae:PA3001 glyceraldehyde 3-phosphate dehydrogenase. | 0.504 |
| APA96072.1 | lysN | NS506_02005 | NS506_07325 | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | 2-aminoadipate transaminase; Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also contributes in the biosynthesis of other amino acids such as leucine; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family; KEGG: aja:AJAP_21515 2-aminoadipate transaminase; Transaminases. | 0.907 |
| APA96072.1 | pgi | NS506_02005 | NS506_01498 | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | Glucose-6-phosphate isomerase; Belongs to the GPI family; KEGG: mva:Mvan_4877 glucose-6-phosphate isomerase. | 0.716 |
| APA96072.1 | tpiA | NS506_02005 | NS506_04156 | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.583 |
| APB01298.1 | APA96072.1 | NS506_07278 | NS506_02005 | (S)-2-hydroxy-acid oxidase; Belongs to the FAD-binding oxidoreductase/transferase type 4 family; Contains 1 FAD-binding PCMH-type domain; KEGG: cct:CC1_16380 glycolate oxidase. | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | 0.922 |
| APB01298.1 | aceA | NS506_07278 | NS506_00197 | (S)-2-hydroxy-acid oxidase; Belongs to the FAD-binding oxidoreductase/transferase type 4 family; Contains 1 FAD-binding PCMH-type domain; KEGG: cct:CC1_16380 glycolate oxidase. | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family; KEGG: mab:MAB_4095c isocitrate lyase. | 0.903 |
| APB01298.1 | aceB | NS506_07278 | NS506_05267 | (S)-2-hydroxy-acid oxidase; Belongs to the FAD-binding oxidoreductase/transferase type 4 family; Contains 1 FAD-binding PCMH-type domain; KEGG: cct:CC1_16380 glycolate oxidase. | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.916 |
| APB01298.1 | eda | NS506_07278 | NS506_03642 | (S)-2-hydroxy-acid oxidase; Belongs to the FAD-binding oxidoreductase/transferase type 4 family; Contains 1 FAD-binding PCMH-type domain; KEGG: cct:CC1_16380 glycolate oxidase. | Belongs to the KHG/KDPG aldolase family; KEGG: msm:MSMEG_3788 2-dehydro-3-deoxyphosphogluconate aldolase. | 0.909 |
| APB01298.1 | lysN | NS506_07278 | NS506_07325 | (S)-2-hydroxy-acid oxidase; Belongs to the FAD-binding oxidoreductase/transferase type 4 family; Contains 1 FAD-binding PCMH-type domain; KEGG: cct:CC1_16380 glycolate oxidase. | 2-aminoadipate transaminase; Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also contributes in the biosynthesis of other amino acids such as leucine; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family; KEGG: aja:AJAP_21515 2-aminoadipate transaminase; Transaminases. | 0.907 |
| aceA | APA96072.1 | NS506_00197 | NS506_02005 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family; KEGG: mab:MAB_4095c isocitrate lyase. | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | 0.953 |
| aceA | APB01298.1 | NS506_00197 | NS506_07278 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family; KEGG: mab:MAB_4095c isocitrate lyase. | (S)-2-hydroxy-acid oxidase; Belongs to the FAD-binding oxidoreductase/transferase type 4 family; Contains 1 FAD-binding PCMH-type domain; KEGG: cct:CC1_16380 glycolate oxidase. | 0.903 |
| aceA | aceB | NS506_00197 | NS506_05267 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family; KEGG: mab:MAB_4095c isocitrate lyase. | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.993 |
| aceA | eda | NS506_00197 | NS506_03642 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family; KEGG: mab:MAB_4095c isocitrate lyase. | Belongs to the KHG/KDPG aldolase family; KEGG: msm:MSMEG_3788 2-dehydro-3-deoxyphosphogluconate aldolase. | 0.912 |
| aceA | lysN | NS506_00197 | NS506_07325 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family; KEGG: mab:MAB_4095c isocitrate lyase. | 2-aminoadipate transaminase; Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also contributes in the biosynthesis of other amino acids such as leucine; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family; KEGG: aja:AJAP_21515 2-aminoadipate transaminase; Transaminases. | 0.900 |
| aceB | APA96072.1 | NS506_05267 | NS506_02005 | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...] | 0.951 |
