| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APA94526.1 | APA96742.1 | NS506_00444 | NS506_02681 | Hypothetical protein. | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | 0.723 |
| APA94526.1 | APA97135.1 | NS506_00444 | NS506_03079 | Hypothetical protein. | Prolyl aminopeptidase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. Since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidation is therefore likely to be the endogenous menaquinone found in the memb [...] | 0.747 |
| APA94526.1 | APA97697.1 | NS506_00444 | NS506_03647 | Hypothetical protein. | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | 0.770 |
| APA94526.1 | APA98205.1 | NS506_00444 | NS506_04157 | Hypothetical protein. | Hypothetical protein. | 0.743 |
| APA94526.1 | APA98505.1 | NS506_00444 | NS506_04457 | Hypothetical protein. | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | 0.683 |
| APA94526.1 | cofD | NS506_00444 | NS506_02072 | Hypothetical protein. | 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.742 |
| APA94526.1 | cofE | NS506_00444 | NS506_02073 | Hypothetical protein. | Coenzyme F420-0:L-glutamate ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. | 0.716 |
| APA94526.1 | fgd1 | NS506_00444 | NS506_01163 | Hypothetical protein. | Glucose-6-phosphate dehydrogenase (coenzyme-F420); Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. | 0.852 |
| APA95378.1 | APA96742.1 | NS506_01305 | NS506_02681 | Putative coenzyme F420-dependent oxidoreductase. | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | 0.628 |
| APA95378.1 | APA97135.1 | NS506_01305 | NS506_03079 | Putative coenzyme F420-dependent oxidoreductase. | Prolyl aminopeptidase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. Since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidation is therefore likely to be the endogenous menaquinone found in the memb [...] | 0.692 |
| APA95378.1 | APA97697.1 | NS506_01305 | NS506_03647 | Putative coenzyme F420-dependent oxidoreductase. | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | 0.765 |
| APA95378.1 | APA98205.1 | NS506_01305 | NS506_04157 | Putative coenzyme F420-dependent oxidoreductase. | Hypothetical protein. | 0.683 |
| APA95378.1 | APA98505.1 | NS506_01305 | NS506_04457 | Putative coenzyme F420-dependent oxidoreductase. | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | 0.650 |
| APA95378.1 | cofD | NS506_01305 | NS506_02072 | Putative coenzyme F420-dependent oxidoreductase. | 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.757 |
| APA95378.1 | cofE | NS506_01305 | NS506_02073 | Putative coenzyme F420-dependent oxidoreductase. | Coenzyme F420-0:L-glutamate ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. | 0.775 |
| APA96742.1 | APA94526.1 | NS506_02681 | NS506_00444 | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | Hypothetical protein. | 0.723 |
| APA96742.1 | APA95378.1 | NS506_02681 | NS506_01305 | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | Putative coenzyme F420-dependent oxidoreductase. | 0.628 |
| APA96742.1 | APA97135.1 | NS506_02681 | NS506_03079 | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | Prolyl aminopeptidase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. Since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidation is therefore likely to be the endogenous menaquinone found in the memb [...] | 0.768 |
| APA96742.1 | APA97697.1 | NS506_02681 | NS506_03647 | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | 0.770 |
| APA96742.1 | APA98205.1 | NS506_02681 | NS506_04157 | F420H(2)-dependent quinone reductase; Involved in a F420-dependent anti-oxidant mechanism that protects M. tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadio; since menaquinone is the sole quinone electron carrier in the respiratory chain in M. tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidat [...] | Hypothetical protein. | 0.749 |
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