| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APA96187.1 | APA98182.1 | NS506_02120 | NS506_04134 | Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released. This sigma factor is involved in heat shock and oxidative stress responses; Belongs to the sigma-70 factor family. ECF subfamily. | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | 0.651 |
| APA96187.1 | rpoA | NS506_02120 | NS506_07500 | Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released. This sigma factor is involved in heat shock and oxidative stress responses; Belongs to the sigma-70 factor family. ECF subfamily. | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.881 |
| APA96187.1 | rpoB | NS506_02120 | NS506_00040 | Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released. This sigma factor is involved in heat shock and oxidative stress responses; Belongs to the sigma-70 factor family. ECF subfamily. | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.938 |
| APA96187.1 | rpoC | NS506_02120 | NS506_00039 | Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released. This sigma factor is involved in heat shock and oxidative stress responses; Belongs to the sigma-70 factor family. ECF subfamily. | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.939 |
| APA98182.1 | APA96187.1 | NS506_04134 | NS506_02120 | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released. This sigma factor is involved in heat shock and oxidative stress responses; Belongs to the sigma-70 factor family. ECF subfamily. | 0.651 |
| APA98182.1 | APA99217.1 | NS506_04134 | NS506_05171 | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | Uncharacterized protein; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 PPM-type phosphatase domain; Contains 1 STAS domain; KEGG: mmc:Mmcs_0350 null; Phosphotransferases with a nitrogenous group as acceptor. | 0.994 |
| APA98182.1 | APA99218.1 | NS506_04134 | NS506_05172 | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | Anti-sigma-F factor antagonist RsfB; Positive regulator of sigma-F (SigF) activity. Binds to anti-sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription (By similarity); Belongs to the anti-sigma-factor antagonist family; Contains 1 STAS domain. | 0.787 |
| APA98182.1 | ftsZ | NS506_04134 | NS506_03357 | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.617 |
| APA98182.1 | rpoA | NS506_04134 | NS506_07500 | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.843 |
| APA98182.1 | rpoB | NS506_04134 | NS506_00040 | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.937 |
| APA98182.1 | rpoC | NS506_04134 | NS506_00039 | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.923 |
| APA98182.1 | rsbT | NS506_04134 | NS506_05169 | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | Non-specific serine/threonine protein kinase; Provides the crucial link between the upstream module (communication of environmental stress) and the downstream module (integration of the environmental signals with signals of energy stress) that compose the signal transduction pathway controlling the sigma-B factor. Phosphorylates and inactivates its specific antagonist protein RsbS thanks to its serine kinase activity. Upon phosphorylation of RsbS, RsbT is released to stimulate RsbU, a PP2C phosphatase, thereby initiating the signaling cascade that ultimately activates sigma-B. The acti [...] | 0.829 |
| APA98182.1 | rsbW | NS506_04134 | NS506_04135 | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | Non-specific serine/threonine protein kinase; A cognate anti-sigma factor for alternative sigma factor SigF. Alternative sigma factors are held in an inactive form by an anti-sigma factor. Binds ATP and GTP, may hydrolyze both (By similarity); Belongs to the anti-sigma-factor family; KEGG: nfa:nfa36040 serine/threonine-protein kinase RsbW. | 0.984 |
| APA98182.1 | trxB | NS506_04134 | NS506_00286 | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | Thioredoxin-disulfide reductase; Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be HoxX) and then acts in conjunction with sigma-54 as a transcriptional activator. Contains 1 response regulatory domain; Contains 1 sigma-54 factor interaction domain; KEGG: ncy:NOCYR_5110 thioredoxin reductase (NADPH). | 0.689 |
| APA99217.1 | APA98182.1 | NS506_05171 | NS506_04134 | Uncharacterized protein; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 PPM-type phosphatase domain; Contains 1 STAS domain; KEGG: mmc:Mmcs_0350 null; Phosphotransferases with a nitrogenous group as acceptor. | RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Its regulon, determined following disruption, consists of 38 genes decreased in exponential phase, 187 genes decreased in early S-phase, and 277 genes decreased in late S-phase ; Belongs to the sigma-70 factor family. | 0.994 |
| APA99217.1 | APA99218.1 | NS506_05171 | NS506_05172 | Uncharacterized protein; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 PPM-type phosphatase domain; Contains 1 STAS domain; KEGG: mmc:Mmcs_0350 null; Phosphotransferases with a nitrogenous group as acceptor. | Anti-sigma-F factor antagonist RsfB; Positive regulator of sigma-F (SigF) activity. Binds to anti-sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription (By similarity); Belongs to the anti-sigma-factor antagonist family; Contains 1 STAS domain. | 0.999 |
| APA99217.1 | ftsZ | NS506_05171 | NS506_03357 | Uncharacterized protein; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 PPM-type phosphatase domain; Contains 1 STAS domain; KEGG: mmc:Mmcs_0350 null; Phosphotransferases with a nitrogenous group as acceptor. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.667 |
| APA99217.1 | rpoB | NS506_05171 | NS506_00040 | Uncharacterized protein; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 PPM-type phosphatase domain; Contains 1 STAS domain; KEGG: mmc:Mmcs_0350 null; Phosphotransferases with a nitrogenous group as acceptor. | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.432 |
| APA99217.1 | rpoC | NS506_05171 | NS506_00039 | Uncharacterized protein; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 PPM-type phosphatase domain; Contains 1 STAS domain; KEGG: mmc:Mmcs_0350 null; Phosphotransferases with a nitrogenous group as acceptor. | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.640 |
| APA99217.1 | rsbT | NS506_05171 | NS506_05169 | Uncharacterized protein; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 PPM-type phosphatase domain; Contains 1 STAS domain; KEGG: mmc:Mmcs_0350 null; Phosphotransferases with a nitrogenous group as acceptor. | Non-specific serine/threonine protein kinase; Provides the crucial link between the upstream module (communication of environmental stress) and the downstream module (integration of the environmental signals with signals of energy stress) that compose the signal transduction pathway controlling the sigma-B factor. Phosphorylates and inactivates its specific antagonist protein RsbS thanks to its serine kinase activity. Upon phosphorylation of RsbS, RsbT is released to stimulate RsbU, a PP2C phosphatase, thereby initiating the signaling cascade that ultimately activates sigma-B. The acti [...] | 0.989 |