| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APB00546.1 | aceE | NS506_06510 | NS506_03003 | Urea carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.936 |
| APB00546.1 | eno | NS506_06510 | NS506_01692 | Urea carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.601 |
| APB00546.1 | korA | NS506_06510 | NS506_05539 | Urea carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 2-oxoglutarate synthase; Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha- ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitr; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M. tuberculosis during infection, flux through KOR likely represents a [...] | 0.934 |
| APB00546.1 | korB | NS506_06510 | NS506_05538 | Urea carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 2-oxoglutarate synthase; Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha- ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitr; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M. tuberculosis during infection, flux through KOR likely represents a [...] | 0.912 |
| APB00546.1 | pckA | NS506_06510 | NS506_01039 | Urea carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.952 |
| APB00546.1 | pckG | NS506_06510 | NS506_03876 | Urea carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.952 |
| APB00546.1 | ppc | NS506_06510 | NS506_05975 | Urea carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. | 0.976 |
| APB00546.1 | ppdK | NS506_06510 | NS506_06829 | Urea carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Pyruvate, phosphate dikinase; Catalyzes the reversible phosphorylation of pyruvate and phosphate. In E. histolytica and C. symbiosus, PPDK functions in the direction of ATP synthesis. Belongs to the PEP-utilizing enzyme family; KEGG: mit:OCO_11590 pyruvate, orthophosphate dikinase. | 0.916 |
| APB00546.1 | ppsA | NS506_06510 | NS506_04397 | Urea carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Pyruvate, water dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.911 |
| APB00546.1 | sfcA | NS506_06510 | NS506_01954 | Urea carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Malate dehydrogenase (oxaloacetate-decarboxylating); In the N-terminal sectio; belongs to the malic enzymes family; In the C-terminal sectio; belongs to the phosphate acetyltransferase and butyryltransferase family; KEGG: chm:B842_03185 malate dehydrogenase (oxaloacetate-decarboxylating). | 0.963 |
| aceE | APB00546.1 | NS506_03003 | NS506_06510 | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Urea carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.936 |
| aceE | eno | NS506_03003 | NS506_01692 | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.443 |
| aceE | korA | NS506_03003 | NS506_05539 | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 2-oxoglutarate synthase; Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha- ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitr; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M. tuberculosis during infection, flux through KOR likely represents a [...] | 0.933 |
| aceE | korB | NS506_03003 | NS506_05538 | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 2-oxoglutarate synthase; Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha- ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitr; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M. tuberculosis during infection, flux through KOR likely represents a [...] | 0.912 |
| aceE | pckA | NS506_03003 | NS506_01039 | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.819 |
| aceE | pckG | NS506_03003 | NS506_03876 | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.819 |
| aceE | ppc | NS506_03003 | NS506_05975 | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. | 0.456 |
| aceE | ppdK | NS506_03003 | NS506_06829 | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate, phosphate dikinase; Catalyzes the reversible phosphorylation of pyruvate and phosphate. In E. histolytica and C. symbiosus, PPDK functions in the direction of ATP synthesis. Belongs to the PEP-utilizing enzyme family; KEGG: mit:OCO_11590 pyruvate, orthophosphate dikinase. | 0.910 |
| aceE | ppsA | NS506_03003 | NS506_04397 | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate, water dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.921 |
| aceE | sfcA | NS506_03003 | NS506_01954 | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Malate dehydrogenase (oxaloacetate-decarboxylating); In the N-terminal sectio; belongs to the malic enzymes family; In the C-terminal sectio; belongs to the phosphate acetyltransferase and butyryltransferase family; KEGG: chm:B842_03185 malate dehydrogenase (oxaloacetate-decarboxylating). | 0.917 |
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