| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APA95920.1 | dinB-2 | NS506_01852 | NS506_04461 | DNA-3-methyladenine glycosylase II; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3- methylguanine, 7-methylguanine, O2-methylthymine, and O2- methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); The methylation of Alka by methylphosphotriesters in DNA [...] | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.660 |
| APA95920.1 | dpo1 | NS506_01852 | NS506_03569 | DNA-3-methyladenine glycosylase II; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3- methylguanine, 7-methylguanine, O2-methylthymine, and O2- methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); The methylation of Alka by methylphosphotriesters in DNA [...] | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.741 |
| APA95920.1 | recA | NS506_01852 | NS506_06105 | DNA-3-methyladenine glycosylase II; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3- methylguanine, 7-methylguanine, O2-methylthymine, and O2- methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); The methylation of Alka by methylphosphotriesters in DNA [...] | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.723 |
| APA95920.1 | uvrB | NS506_01852 | NS506_03597 | DNA-3-methyladenine glycosylase II; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3- methylguanine, 7-methylguanine, O2-methylthymine, and O2- methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); The methylation of Alka by methylphosphotriesters in DNA [...] | UvrABC system protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and t [...] | 0.423 |
| APA98510.1 | dinB-2 | NS506_04462 | NS506_04461 | Hypothetical protein. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.773 |
| APB01426.1 | APB01439.1 | NS506_07406 | NS506_07419 | DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase; Belongs to the DNA polymerase type-C family. DnaE2 subfamily; KEGG: mcb:Mycch_1132 error-prone DNA polymerase. | Uncharacterized protein; Membrane; Transmembrane; Transmembrane helix. | 0.940 |
| APB01426.1 | dinB-2 | NS506_07406 | NS506_04461 | DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase; Belongs to the DNA polymerase type-C family. DnaE2 subfamily; KEGG: mcb:Mycch_1132 error-prone DNA polymerase. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.754 |
| APB01426.1 | dnaN | NS506_07406 | NS506_00632 | DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase; Belongs to the DNA polymerase type-C family. DnaE2 subfamily; KEGG: mcb:Mycch_1132 error-prone DNA polymerase. | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | 0.889 |
| APB01426.1 | dpo1 | NS506_07406 | NS506_03569 | DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase; Belongs to the DNA polymerase type-C family. DnaE2 subfamily; KEGG: mcb:Mycch_1132 error-prone DNA polymerase. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.675 |
| APB01426.1 | lexA-2 | NS506_07406 | NS506_04258 | DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase; Belongs to the DNA polymerase type-C family. DnaE2 subfamily; KEGG: mcb:Mycch_1132 error-prone DNA polymerase. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.430 |
| APB01426.1 | lexA-3 | NS506_07406 | NS506_06019 | DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase; Belongs to the DNA polymerase type-C family. DnaE2 subfamily; KEGG: mcb:Mycch_1132 error-prone DNA polymerase. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.641 |
| APB01426.1 | recA | NS506_07406 | NS506_06105 | DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase; Belongs to the DNA polymerase type-C family. DnaE2 subfamily; KEGG: mcb:Mycch_1132 error-prone DNA polymerase. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.709 |
| APB01439.1 | APB01426.1 | NS506_07419 | NS506_07406 | Uncharacterized protein; Membrane; Transmembrane; Transmembrane helix. | DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase; Belongs to the DNA polymerase type-C family. DnaE2 subfamily; KEGG: mcb:Mycch_1132 error-prone DNA polymerase. | 0.940 |
| APB01439.1 | dinB-2 | NS506_07419 | NS506_04461 | Uncharacterized protein; Membrane; Transmembrane; Transmembrane helix. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.790 |
| APB01439.1 | lexA-3 | NS506_07419 | NS506_06019 | Uncharacterized protein; Membrane; Transmembrane; Transmembrane helix. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.423 |
| dinB-2 | APA95920.1 | NS506_04461 | NS506_01852 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA-3-methyladenine glycosylase II; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3- methylguanine, 7-methylguanine, O2-methylthymine, and O2- methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); The methylation of Alka by methylphosphotriesters in DNA [...] | 0.660 |
| dinB-2 | APA98510.1 | NS506_04461 | NS506_04462 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Hypothetical protein. | 0.773 |
| dinB-2 | APB01426.1 | NS506_04461 | NS506_07406 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase; Belongs to the DNA polymerase type-C family. DnaE2 subfamily; KEGG: mcb:Mycch_1132 error-prone DNA polymerase. | 0.754 |
| dinB-2 | APB01439.1 | NS506_04461 | NS506_07419 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Uncharacterized protein; Membrane; Transmembrane; Transmembrane helix. | 0.790 |
| dinB-2 | dnaN | NS506_04461 | NS506_00632 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | 0.921 |
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