| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APA98184.1 | mtnA | NS506_04136 | NS506_04590 | Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family; KEGG: mbj:KQ51_01698 ribulose-phosphate 3-epimerase. | S-methyl-5-thioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the aldolase class II family. | 0.790 |
| aprT | mtaP | NS506_05596 | NS506_07488 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.908 |
| aprT | mtnA | NS506_05596 | NS506_04590 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | S-methyl-5-thioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the aldolase class II family. | 0.827 |
| fucA | metH | NS506_02412 | NS506_05146 | L-fuculose-phosphate aldolase; Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde; Belongs to the aldolase class II family. AraD/FucA subfamily; KEGG: req:REQ_03610 L-fuculose-phosphate aldolase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.612 |
| fucA | mtaP | NS506_02412 | NS506_07488 | L-fuculose-phosphate aldolase; Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde; Belongs to the aldolase class II family. AraD/FucA subfamily; KEGG: req:REQ_03610 L-fuculose-phosphate aldolase. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.451 |
| fucA | mtnA | NS506_02412 | NS506_04590 | L-fuculose-phosphate aldolase; Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde; Belongs to the aldolase class II family. AraD/FucA subfamily; KEGG: req:REQ_03610 L-fuculose-phosphate aldolase. | S-methyl-5-thioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the aldolase class II family. | 0.729 |
| fucA | mtnD | NS506_02412 | NS506_04591 | L-fuculose-phosphate aldolase; Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde; Belongs to the aldolase class II family. AraD/FucA subfamily; KEGG: req:REQ_03610 L-fuculose-phosphate aldolase. | Acireductone dioxygenase (Ni(2+)-requiring); Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.655 |
| fucA | rbcL | NS506_02412 | NS506_04565 | L-fuculose-phosphate aldolase; Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde; Belongs to the aldolase class II family. AraD/FucA subfamily; KEGG: req:REQ_03610 L-fuculose-phosphate aldolase. | Ribulose-bisphosphate carboxylase; Both reactions occur simultaneously and in competition at the same active site. Belongs to the RuBisCO large chain family. Type I subfamily; KEGG: noc:Noc_0333 ribulose-bisphosphate carboxylase large chain. | 0.610 |
| metF | metH | NS506_03337 | NS506_05146 | Belongs to the methylenetetrahydrofolate reductase family; KEGG: nno:NONO_c23500 methylenetetrahydrofolate reductase (NADPH). | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.997 |
| metF | mtnA | NS506_03337 | NS506_04590 | Belongs to the methylenetetrahydrofolate reductase family; KEGG: nno:NONO_c23500 methylenetetrahydrofolate reductase (NADPH). | S-methyl-5-thioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the aldolase class II family. | 0.807 |
| metF | mtnD | NS506_03337 | NS506_04591 | Belongs to the methylenetetrahydrofolate reductase family; KEGG: nno:NONO_c23500 methylenetetrahydrofolate reductase (NADPH). | Acireductone dioxygenase (Ni(2+)-requiring); Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.557 |
| metF | rbcL | NS506_03337 | NS506_04565 | Belongs to the methylenetetrahydrofolate reductase family; KEGG: nno:NONO_c23500 methylenetetrahydrofolate reductase (NADPH). | Ribulose-bisphosphate carboxylase; Both reactions occur simultaneously and in competition at the same active site. Belongs to the RuBisCO large chain family. Type I subfamily; KEGG: noc:Noc_0333 ribulose-bisphosphate carboxylase large chain. | 0.515 |
| metH | fucA | NS506_05146 | NS506_02412 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | L-fuculose-phosphate aldolase; Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde; Belongs to the aldolase class II family. AraD/FucA subfamily; KEGG: req:REQ_03610 L-fuculose-phosphate aldolase. | 0.612 |
| metH | metF | NS506_05146 | NS506_03337 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Belongs to the methylenetetrahydrofolate reductase family; KEGG: nno:NONO_c23500 methylenetetrahydrofolate reductase (NADPH). | 0.997 |
| metH | mtnA | NS506_05146 | NS506_04590 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-methyl-5-thioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the aldolase class II family. | 0.976 |
| metH | mtnC | NS506_05146 | NS506_04592 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Acireductone synthase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. | 0.474 |
| metH | mtnD | NS506_05146 | NS506_04591 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Acireductone dioxygenase (Ni(2+)-requiring); Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.797 |
| metH | odc1 | NS506_05146 | NS506_05988 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Belongs to the Orn/Lys/Arg decarboxylase class-II family; KEGG: nbr:O3I_029700 ornithine decarboxylase. | 0.666 |
| metH | rbcL | NS506_05146 | NS506_04565 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ribulose-bisphosphate carboxylase; Both reactions occur simultaneously and in competition at the same active site. Belongs to the RuBisCO large chain family. Type I subfamily; KEGG: noc:Noc_0333 ribulose-bisphosphate carboxylase large chain. | 0.616 |
| mtaP | aprT | NS506_07488 | NS506_05596 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.908 |
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