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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APA98814.1Cadmium-exporting ATPase; Involved in heavy metal homeostasis. Probably exports nickel and cobalt ions out of the cell (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily; KEGG: rsa:RSal33209_2182 Cd2+/Zn2+-exporting ATPase. (674 aa)    
Predicted Functional Partners:
APA95712.1
Copper chaperone CopZ; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA) (By similarity); Contains 1 HMA domain.
  
 
 0.713
APA98842.1
Hypothetical protein.
  
 
 0.642
mmuM
Homocysteine S-methyltransferase; Catalyzes methyl transfer from S-methylmethionine (SMM) to adenosyl-L-homocysteine (AdoMet). SMM degradation (by HMT-1, HMT-2 and HMT-3) and biosynthesis (by MMT1) constitute the SMM cycle in plants, which is probably required to achieve short term control of AdoMet level. Contains 1 Hcy-binding domain; KEGG: aym:YM304_04390 homocysteine S-methyltransferase.
       0.563
APA98813.1
Hypothetical protein.
       0.535
sod1
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.
  
 
 0.528
APB01509.1
Copper-sensing transcriptional repressor RicR; Under low copper conditions, represses the expression of lpqS, Rv2963, mymT, socA, socB, mmcO and its own expression. In the presence of copper, RicR dissociates from DNA, leading to the expression of the target genes. Members of the RicR regulon are important for copper resistance during infections and full virulence in a mouse model of infection; Belongs to the CsoR family.
 
  
 0.508
APB00682.1
Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity. Belongs to the multicopper oxidase family. CopA subfamily.
 
  
 0.460
APB00708.1
KEGG: aav:Aave_4523 superoxide dismutase, Cu-Zn family.
   
 0.444
mhpC
2-hydroxy-6-oxonona-2,4-dienedioate hydrolase; Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10), 2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5- oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Also involved in biphenyl and polychlorinated biphenyls (PCBs) degradation; Belongs to the AB hydrolase superfamily. HsaD family; KEGG: tcu:Tcur_3522 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase.
       0.423
APA96948.1
HTH-type transcriptional repressor SmtB; Transcriptional regulator involved in zinc homeostasis. Represses the expression of the smtB-zur operon in the absence of zinc. Could act as the metal sensor that controls the expression of zur in response to zinc availability (By similarity); Contains 1 HTH arsR-type DNA-binding domain.
 
  
 0.414
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
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