| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APA94915.1 | APA99133.1 | NS506_00836 | NS506_05087 | Bacterial proteasome activator; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction; Belongs to the Bpa family. | Pup deamidase/depupylase; Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugation. Also displays depupylase (DPUP) activity, removing conjugated Pup from target protein; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins (By similarity); Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily; KEGG: nfa:nfa31740 proteasome accessory [...] | 0.736 |
| APA94915.1 | arc | NS506_00836 | NS506_05126 | Bacterial proteasome activator; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction; Belongs to the Bpa family. | Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.844 |
| APA94915.1 | pafA | NS506_00836 | NS506_05082 | Bacterial proteasome activator; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction; Belongs to the Bpa family. | Pup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.777 |
| APA94915.1 | psmA | NS506_00836 | NS506_05084 | Bacterial proteasome activator; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction; Belongs to the Bpa family. | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.986 |
| APA94915.1 | psmB | NS506_00836 | NS506_05085 | Bacterial proteasome activator; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction; Belongs to the Bpa family. | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.965 |
| APA94915.1 | pup | NS506_00836 | NS506_05086 | Bacterial proteasome activator; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction; Belongs to the Bpa family. | Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.704 |
| APA99133.1 | APA94915.1 | NS506_05087 | NS506_00836 | Pup deamidase/depupylase; Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugation. Also displays depupylase (DPUP) activity, removing conjugated Pup from target protein; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins (By similarity); Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily; KEGG: nfa:nfa31740 proteasome accessory [...] | Bacterial proteasome activator; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction; Belongs to the Bpa family. | 0.736 |
| APA99133.1 | arc | NS506_05087 | NS506_05126 | Pup deamidase/depupylase; Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugation. Also displays depupylase (DPUP) activity, removing conjugated Pup from target protein; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins (By similarity); Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily; KEGG: nfa:nfa31740 proteasome accessory [...] | Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.904 |
| APA99133.1 | pafA | NS506_05087 | NS506_05082 | Pup deamidase/depupylase; Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugation. Also displays depupylase (DPUP) activity, removing conjugated Pup from target protein; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins (By similarity); Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily; KEGG: nfa:nfa31740 proteasome accessory [...] | Pup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.466 |
| APA99133.1 | psmA | NS506_05087 | NS506_05084 | Pup deamidase/depupylase; Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugation. Also displays depupylase (DPUP) activity, removing conjugated Pup from target protein; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins (By similarity); Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily; KEGG: nfa:nfa31740 proteasome accessory [...] | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.948 |
| APA99133.1 | psmB | NS506_05087 | NS506_05085 | Pup deamidase/depupylase; Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugation. Also displays depupylase (DPUP) activity, removing conjugated Pup from target protein; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins (By similarity); Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily; KEGG: nfa:nfa31740 proteasome accessory [...] | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.945 |
| APA99133.1 | pup | NS506_05087 | NS506_05086 | Pup deamidase/depupylase; Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugation. Also displays depupylase (DPUP) activity, removing conjugated Pup from target protein; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins (By similarity); Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily; KEGG: nfa:nfa31740 proteasome accessory [...] | Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.942 |
| APB01182.1 | arc | NS506_07157 | NS506_05126 | CysO-cysteine peptidase; Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO; Belongs to the peptidase M67A family; Contains 1 MPN (JAB/Mov34) domain. | Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.958 |
| APB01182.1 | glpK | NS506_07157 | NS506_07107 | CysO-cysteine peptidase; Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO; Belongs to the peptidase M67A family; Contains 1 MPN (JAB/Mov34) domain. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.938 |
| APB01182.1 | glpK-2 | NS506_07157 | NS506_07109 | CysO-cysteine peptidase; Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO; Belongs to the peptidase M67A family; Contains 1 MPN (JAB/Mov34) domain. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.938 |
| APB01182.1 | glpK-3 | NS506_07157 | NS506_07324 | CysO-cysteine peptidase; Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO; Belongs to the peptidase M67A family; Contains 1 MPN (JAB/Mov34) domain. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.938 |
| APB01182.1 | psmA | NS506_07157 | NS506_05084 | CysO-cysteine peptidase; Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO; Belongs to the peptidase M67A family; Contains 1 MPN (JAB/Mov34) domain. | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.946 |
| APB01182.1 | psmB | NS506_07157 | NS506_05085 | CysO-cysteine peptidase; Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO; Belongs to the peptidase M67A family; Contains 1 MPN (JAB/Mov34) domain. | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.946 |
| arc | APA94915.1 | NS506_05126 | NS506_00836 | Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | Bacterial proteasome activator; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction; Belongs to the Bpa family. | 0.844 |
| arc | APA99133.1 | NS506_05126 | NS506_05087 | Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | Pup deamidase/depupylase; Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugation. Also displays depupylase (DPUP) activity, removing conjugated Pup from target protein; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins (By similarity); Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily; KEGG: nfa:nfa31740 proteasome accessory [...] | 0.904 |
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