STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
APA99567.1Fatty acyl-CoA reductase; Catalyzes the NADPH-dependent reduction of long chain acyl-CoA (with chain lengths of 14 to 22 carbons) to the corresponding aldehyde; Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: srr:SerAS9_3299 meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase; With NAD(+) or NADP(+) as acceptor. (863 aa)    
Predicted Functional Partners:
APA99455.1
o-succinylbenzoate--CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA). May be involved in the biosynthesis of menaquinone (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily; KEGG: mts:MTES_2345 O-succinylbenzoic acid--CoA ligase.
  
     0.702
APA98371.1
Bacitracin synthase; Activates five amino acids, incorporates two D-amino acids, releases and cyclizes the mature bacitracin. Belongs to the ATP-dependent AMP-binding enzyme family; Contains 5 acyl carrier domains.
 
 
 0.696
APA96082.1
Long-chain-fatty-acid--CoA ligase; Belongs to the ATP-dependent AMP-binding enzyme family; KEGG: sth:STH3016 long-chain acyl-CoA synthetase.
  
   
 0.695
APA99566.1
Cyclohexanone monooxygenase; Catalyzes a Baeyer-Villiger oxidation reaction, i. e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters or lactones using NADPH and/or NADH as an electron donor. Thus, can convert bicyclo[3. 2. 0]hept-2-en-6-one into the oxidative lactone products 2-oxabicyclo[3. 3. 0]oct-6-en-3-one and 3-oxabicyclo[3. 3. 0]oct-6-en- 2-one. Is also able to catalyze the sulfoxidation of methyl phenyl sulfide (thioanisole); Belongs to the FAD-binding monooxygenase family; KEGG: mgi:Mflv_4103 cyclohexanone monoox [...]
  
    0.676
APB00106.1
Long-chain-fatty-acid--AMP ligase FadD32; Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase (PKS) for further chain extension; Belongs to the ATP-dependent AMP-binding enzyme family.
 
 
0.675
APA99518.1
Aspartate racemase; This protein is a multifunctional enzyme, able to activate and polymerize the amino acids Pro, Val, Orn and Leu. Activation sites for these AA consist of individual domains. Belongs to the ATP-dependent AMP-binding enzyme family; Contains 4 acyl carrier domains; KEGG: rha:RHA1_ro06664 aspartate racemase.
 
 
 0.674
APB01673.1
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
 
 
 0.670
APA98458.1
Acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family; KEGG: pgv:SL003B_1091 acetyl-CoA synthetase.
 
 
 0.649
APB01742.1
2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase; Catalyzes the activation of 2-hydroxy-7-methoxy-5- methyl-1-naphthoate in the biosynthesis of the naphthoate moiety of the neocarzinostatin chromophore. Also catalyzes the activation of other 1-naphthoic acid analogs such as 2-hydroxy-5-methyl-1- naphthoate or 2,7-dihydroxy-5-methyl-1-naphthoate in vitro; Belongs to the ATP-dependent AMP-binding enzyme family.
 
 
 0.628
APB01626.1
Erythronolide synthase, modules 1 and; Contains 3 acyl carrier domains.
  
 0.606
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
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