STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
APA99657.1Cytosine deaminase; Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5- fluorocytosine (5FC) to 5-fluorouracil (5FU; this activity allows the formation of a cytotoxic chemotherapeutic agent from a non- cytotoxic precursor; Belongs to the cytosine deaminase family; KEGG: rpj:N234_0 [...] (421 aa)    
Predicted Functional Partners:
codA
Cytosine deaminase; Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine; Belongs to the MTA/SAH deaminase family; KEGG: hoe:IMCC20628_00279 cytosine deaminase.
 
  
 
0.945
APA97592.1
Creatininase; KEGG: ncy:NOCYR_1575 creatinine amidohydrolase.
 
  
  0.922
deoA
Thymidine phosphorylase; May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family; KEGG: cax:CATYP_03945 thymidine phosphorylase.
    
 0.914
punA
Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
  
 
 0.912
APB00364.1
Belongs to the cytidine and deoxycytidylate deaminase family; Contains 1 CMP/dCMP-type deaminase domain; KEGG: paeq:R50912_02760 tRNA(adenine34) deaminase.
    
 0.909
pyrR
Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
    
 0.906
ppnP
UPF0345 protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.
     
  0.900
APA99656.1
HTH-type transcriptional repressor CsiR; Modulates expression of csiD and lhgO in a temporal manner during entry into stationary phase or during the first few hours of carbon starvation; Contains 1 HTH gntR-type DNA-binding domain.
       0.567
APB00366.1
Probable purine-cytosine permease; Belongs to the purine-cytosine permease (2. A. 39) family.
 
  
 0.426
APA99651.1
Hypothetical protein.
 
     0.405
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.