STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APA99943.1CoA-disulfide reductase; Catalyzes the four-electron reduction of molecular oxygen to water. Active on beta-NADH, but not on alpha-NADH, beta- NADPH or alpha-NADPH. Under aerobic conditions, oxygen acts as the electron acceptor. Under anaerobic conditions, DCIP and MB can replace oxygen as the electron acceptor; Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family; KEGG: shv:AAT16_03300 CoA-disulfide reductase. (472 aa)    
Predicted Functional Partners:
APA99944.1
Uncharacterized protein; Signal.
  
    0.606
APB00836.1
Nitrite reductase (NADH); Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential; Belongs to the FAD-dependent oxidoreductase family; Contains 1 Rieske domain; KEGG: mca:MCA0591 nitrite reductase (NADH) small subunit.
  
 
 0.580
ribE
Riboflavin synthase; Catalyzes the dismutation of two molecules of 6,7- dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil; Contains 2 lumazine-binding repeats; KEGG: hdu:HD1162 riboflavin synthase.
   
    0.575
thiO
Glycine oxidase; Catalyzes the FAD-dependent oxidative deamination of glycine. Is essential for thiamine biosynthesis since the oxidation of glycine catalyzed by ThiO generates the glycine imine intermediate (dehydroglycine) required for the biosynthesis of the thiazole ring of thiamine pyrophosphate (By similarity); Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity); In the N-term [...]
  
 
 0.566
prnA
Tryptophan 7-halogenase; Involved in the biosynthesis of the antifungal antibiotic pyrrolnitrin. Catalyze the chlorination of tryptophan (Trp) at C7 position to yield 7-chloro-L-tryptophan (7-CLT). The reaction between FADH2, Cl-, and O2 generates the powerful oxidant HOCl, which is presumed to carry out the chlorination reaction. The reaction of HOCl with the active site Lys-79 generates a lysine chloramine, which plays a key role in directing regiospecific chlorination of substrate in this important class of biosynthetic enzymes. It is also able to use bromide ions to generate monobr [...]
  
 
 0.566
APB00374.1
Hypothetical protein.
  
 
 0.566
APB01524.1
Belongs to the ribosomal protein L36P family.
   
   0.557
gltB
Glutamate synthase (NADPH); Required for the assimilation of symbiotically fixed nitrogen into amino acids in root nodules; Belongs to the glutamate synthase family; Contains 1 glutamine amidotransferase type-2 domain; KEGG: nfa:nfa960 glutamate synthase (NADPH/NADH) large chain.
     
 0.539
APA94768.1
Hypothetical protein.
    
   0.533
rpmE2
Belongs to the ribosomal protein L31P family. Type B subfamily.
   
    0.531
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.