STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APA99981.1C7-cyclitol synthase using sedo-heptulose 7-phosphate, but not ido-heptulose 7-phosphate and 3-deoxy-arabino- heptulosonate 7-phosphate, as a substrate. Involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Belongs to the dehydroquinate synthase family; KEGG: mmi:MMAR_0578 3-dehydroquinate synthase. (407 aa)    
Predicted Functional Partners:
APA99972.1
Glucokinase; KEGG: serr:Ser39006_0221 glucokinase.
 
  
 0.983
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
 0.968
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
  
 0.941
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.931
aroE
Shikimate dehydrogenase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis; In the N-terminal sectio; belongs to the dehydroquinate synthase family; In the 2nd sectio; belongs to the EPSP synthase family; In the 3rd sectio; belongs to the shikimate kinase family; In the 4th sectio; belongs to the type-I 3- dehydroquinase family; In the C-terminal sectio; belongs to the shikimate dehydrogenase family; KEGG: mtu:Rv2552c shikimate dehydrogenase.
  
 0.862
APA99980.1
Beta-ketoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids; Belongs to the FabH family; KEGG: rer:RER_54370 3-oxoacyl-(acy [...]
   
   0.800
butB
L-threonine 3-dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family; KEGG: rbu:PG1C_04345 (R,R)-butanediol dehydrogenase / meso-butanediol dehydrogenase / diacetyl reductase.
     
 0.797
APA99971.1
KEGG: nos:Nos7107_0307 L-iditol 2-dehydrogenase.
     
 0.796
APA99977.1
3-oxoacyl-[acyl-carrier-protein] reductase; NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP- dependent oxidation of L-allo-threonine to L-2-amino-3-keto- butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3- hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L- glycerate; Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: cbd:CBUD_0470 3-oxoacyl-(acyl-carrier protein) reductase.
     
 0.792
APA99974.1
KEGG: sen:SACE_4878 alkanesulfonate monooxygenase.
       0.786
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.