STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (422 aa)    
Predicted Functional Partners:
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 0.999
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
 
 
 0.945
gltB
Glutamate synthase (NADPH); Required for the assimilation of symbiotically fixed nitrogen into amino acids in root nodules; Belongs to the glutamate synthase family; Contains 1 glutamine amidotransferase type-2 domain; KEGG: nfa:nfa960 glutamate synthase (NADPH/NADH) large chain.
    
 0.918
APA95969.1
L-glutamate gamma-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family; KEGG: nfa:nfa47480 1-pyrroline-5-carboxylate dehydrogenase.
  
 
 0.907
pruA
L-glutamate gamma-semialdehyde dehydrogenase; Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes; Belongs to the aldehyde dehydrogenase family; KEGG: rha:RHA1_ro00348 1-pyrroline-5-carboxylate dehydrogenase.
  
 
 0.907
purQ
Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...]
  
 
 0.866
glnA
Glutamate--ammonia ligase; Belongs to the glutamine synthetase family; KEGG: mtu:Rv2222c glutamine synthetase.
    
 0.841
APB00795.1
Hypothetical protein.
  
    0.833
gadB
Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid. Belongs to the group II decarboxylase family; KEGG: nbr:O3I_003125 glutamate decarboxylase.
    
 0.830
APA97880.1
Glutamate--ammonia ligase; Involved in the degradation of isopropylamine, which is a constituent of the herbicides atrazine. Catalyze the ATP- dependent formation of gamma-glutamyl-isopropylamide from isopropylamine and L-glutamate. It can also use aminoalkanes, amino-alcohols (L-alaninol and D-alaninol) and amino-esters as substrates; Belongs to the glutamine synthetase family; KEGG: pla:Plav_2794 glutamine synthetase.
    
 0.829
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (14%) [HD]
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