STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pflA[Formate-C-acetyltransferase]-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (268 aa)    
Predicted Functional Partners:
pflD
Formate C-acetyltransferase; Contains 1 glycine radical domain; Contains 1 PFL domain; KEGG: rge:RGE_05280 formate C-acetyltransferase.
  
 0.989
APB00927.1
Protein-glutamate methylesterase; Involved in the modulation of the chemotaxis syste; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR; Contains 1 cheB-type methylesterase domain; Contains 1 response regulatory domain; KEGG: xcc:XCC2705 two-component system, chemotaxis family, response regulator CheB.
       0.503
bkdA
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2); KEGG: sro:Sros_6420 2-oxoisovalerate dehydrogenase E1 component.
   
  
 0.497
APB00924.1
Redox sensor histidine kinase response regulator DevS; Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor; the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaerobic growth) Fe(2+) form is probably active for phosphate transfer. It is probably reduced by flavin nucleotides such as FMN and FAD. May be the primary sensor for CO. Donates a phosphate group to DevR (DosR) (By similarity); Contains 2 GAF domains; Contains 1 histidine kinase domai [...]
  
    0.489
APA95237.1
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
     
 0.479
APB00836.1
Nitrite reductase (NADH); Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential; Belongs to the FAD-dependent oxidoreductase family; Contains 1 Rieske domain; KEGG: mca:MCA0591 nitrite reductase (NADH) small subunit.
  
  
 0.436
APA96560.1
Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
 
   
 0.420
ispF
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
  
  
 0.418
korA
2-oxoglutarate synthase; Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha- ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitr; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M. tuberculosis during infection, flux through KOR likely represents a [...]
     
 0.415
nirB
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family; KEGG: nfa:nfa45610 nitrite reductase (NADH) large subunit.
  
  
 0.404
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (20%) [HD]
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