STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APB01082.1Valine dehydrogenase (NAD(+)); Catalyzes the reversible, NAD-dependent deamination of L-phenylalanine to phenyl pyruvate, ammonia and NADH; Belongs to the Glu/Leu/Phe/Val dehydrogenases family; KEGG: ncy:NOCYR_1282 valine dehydrogenase (NAD+). (359 aa)    
Predicted Functional Partners:
gltB
Glutamate synthase (NADPH); Required for the assimilation of symbiotically fixed nitrogen into amino acids in root nodules; Belongs to the glutamate synthase family; Contains 1 glutamine amidotransferase type-2 domain; KEGG: nfa:nfa960 glutamate synthase (NADPH/NADH) large chain.
  
 
 0.996
bkdA
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2); KEGG: sro:Sros_6420 2-oxoisovalerate dehydrogenase E1 component.
 
 
 0.987
APA97299.1
Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family; KEGG: nno:NONO_c22830 branched-chain amino acid aminotransferase.
  
 
 0.932
alaA
Valine--pyruvate transaminase; Involved in the biosynthesis of alanine; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family; KEGG: asd:AS9A_4094 alanine-synthesizing transaminase.
  
 
 0.915
APA99893.1
Valine--pyruvate transaminase; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family; KEGG: ncy:NOCYR_2246 alanine-synthesizing transaminase.
  
 
 0.915
idh1
Isocitrate dehydrogenase (NADP(+)); May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency; Belongs to the isocitrate and isopropylmalate dehydrogenases family; KEGG: hdn:Hden_2121 isocitrate dehydrogenase.
   
 0.829
APB01081.1
KEGG: myv:G155_25945 indolepyruvate ferredoxin oxidoreductase.
 
  
 0.818
npdA
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily; Contains 1 deacetylase sirtuin-type domain; KEGG: cai:Caci_7099 NAD-dependent deacetylase; In linear amides.
  
 0.801
APA96072.1
2-oxoglutarate decarboxylase; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which [...]
  
 
 0.709
APA95237.1
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
  
 0.708
Your Current Organism:
Nocardia seriolae
NCBI taxonomy Id: 37332
Other names: ATCC 43993, CCUG 46828, CIP 104778, DSM 44129, IFO 15557, JCM 3360, N. seriolae, NBRC 15557
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.