node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APA94112.1 | APA96593.1 | NS506_00021 | NS506_02529 | HTH-type transcriptional regulator HmrR; Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP; Contains 1 HTH merR-type DNA-binding domain. | Putative HTH-type transcriptional regulator; The imp locus inhibits the extrachromosomal maintenance of the Streptomyces plasmid SLP1. Contains 1 HTH gntR-type DNA-binding domain. | 0.421 |
APA94112.1 | APA98541.1 | NS506_00021 | NS506_04493 | HTH-type transcriptional regulator HmrR; Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP; Contains 1 HTH merR-type DNA-binding domain. | Hypothetical protein. | 0.626 |
APA94112.1 | APA99217.1 | NS506_00021 | NS506_05171 | HTH-type transcriptional regulator HmrR; Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP; Contains 1 HTH merR-type DNA-binding domain. | Uncharacterized protein; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 PPM-type phosphatase domain; Contains 1 STAS domain; KEGG: mmc:Mmcs_0350 null; Phosphotransferases with a nitrogenous group as acceptor. | 0.482 |
APA94112.1 | APB01531.1 | NS506_00021 | NS506_07511 | HTH-type transcriptional regulator HmrR; Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP; Contains 1 HTH merR-type DNA-binding domain. | Putative HTH-type transcriptional regulator; The imp locus inhibits the extrachromosomal maintenance of the Streptomyces plasmid SLP1. Contains 1 HTH gntR-type DNA-binding domain. | 0.421 |
APA94112.1 | APB01876.1 | NS506_00021 | NS506_07861 | HTH-type transcriptional regulator HmrR; Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP; Contains 1 HTH merR-type DNA-binding domain. | Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator regio; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site; Contains 1 HTH merR-type DNA-binding domain. | 0.532 |
APA94112.1 | dnaJ | NS506_00021 | NS506_01108 | HTH-type transcriptional regulator HmrR; Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP; Contains 1 HTH merR-type DNA-binding domain. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.500 |
APA94112.1 | dnaJ-2 | NS506_00021 | NS506_02873 | HTH-type transcriptional regulator HmrR; Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP; Contains 1 HTH merR-type DNA-binding domain. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.500 |
APA96593.1 | APA94112.1 | NS506_02529 | NS506_00021 | Putative HTH-type transcriptional regulator; The imp locus inhibits the extrachromosomal maintenance of the Streptomyces plasmid SLP1. Contains 1 HTH gntR-type DNA-binding domain. | HTH-type transcriptional regulator HmrR; Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP; Contains 1 HTH merR-type DNA-binding domain. | 0.421 |
APA96593.1 | APA98541.1 | NS506_02529 | NS506_04493 | Putative HTH-type transcriptional regulator; The imp locus inhibits the extrachromosomal maintenance of the Streptomyces plasmid SLP1. Contains 1 HTH gntR-type DNA-binding domain. | Hypothetical protein. | 0.480 |
APA96593.1 | APB01876.1 | NS506_02529 | NS506_07861 | Putative HTH-type transcriptional regulator; The imp locus inhibits the extrachromosomal maintenance of the Streptomyces plasmid SLP1. Contains 1 HTH gntR-type DNA-binding domain. | Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator regio; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site; Contains 1 HTH merR-type DNA-binding domain. | 0.501 |
APA97419.1 | APA99146.1 | NS506_03367 | NS506_05100 | KEGG: xcv:XCV2352 4-carboxymuconolactone decarboxylase. | KEGG: srr:SerAS9_3325 4-carboxymuconolactone decarboxylase. | 0.907 |
APA97419.1 | APB01876.1 | NS506_03367 | NS506_07861 | KEGG: xcv:XCV2352 4-carboxymuconolactone decarboxylase. | Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator regio; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site; Contains 1 HTH merR-type DNA-binding domain. | 0.648 |
APA98541.1 | APA94112.1 | NS506_04493 | NS506_00021 | Hypothetical protein. | HTH-type transcriptional regulator HmrR; Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP; Contains 1 HTH merR-type DNA-binding domain. | 0.626 |
APA98541.1 | APA96593.1 | NS506_04493 | NS506_02529 | Hypothetical protein. | Putative HTH-type transcriptional regulator; The imp locus inhibits the extrachromosomal maintenance of the Streptomyces plasmid SLP1. Contains 1 HTH gntR-type DNA-binding domain. | 0.480 |
APA98541.1 | APA99217.1 | NS506_04493 | NS506_05171 | Hypothetical protein. | Uncharacterized protein; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 PPM-type phosphatase domain; Contains 1 STAS domain; KEGG: mmc:Mmcs_0350 null; Phosphotransferases with a nitrogenous group as acceptor. | 0.482 |
APA98541.1 | APB01876.1 | NS506_04493 | NS506_07861 | Hypothetical protein. | Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator regio; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site; Contains 1 HTH merR-type DNA-binding domain. | 0.593 |
APA98541.1 | dnaJ | NS506_04493 | NS506_01108 | Hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.500 |
APA98541.1 | dnaJ-2 | NS506_04493 | NS506_02873 | Hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.500 |
APA99146.1 | APA97419.1 | NS506_05100 | NS506_03367 | KEGG: srr:SerAS9_3325 4-carboxymuconolactone decarboxylase. | KEGG: xcv:XCV2352 4-carboxymuconolactone decarboxylase. | 0.907 |
APA99146.1 | APB01876.1 | NS506_05100 | NS506_07861 | KEGG: srr:SerAS9_3325 4-carboxymuconolactone decarboxylase. | Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator regio; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site; Contains 1 HTH merR-type DNA-binding domain. | 0.657 |